Broad bean (Vicia faba L.) caused abnormal lipid metabolism in grass carp (Ctenopharyngodon idellus) liver: Insight from the gut microbiota–liver axis

IF 7.4 Q1 FOOD SCIENCE & TECHNOLOGY Food frontiers Pub Date : 2024-03-07 DOI:10.1002/fft2.377
Bing Fu, Huawei Ma, Huici Yang, Mengping Zheng, Junming Zhang, Yichao Li, Yihui Du, Guangjun Wang, Jingjing Tian, Kai Zhang, Yun Xia, Zhifei Li, Wangbao Gong, Hongyan Li, Jun Xie, Huirong Yang, Ermeng Yu
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Abstract

Broad bean (Vicia faba L.) has received attention from the food and animal feed industries as a sustainable, inexpensive, and versatile plant-based protein source. However, long-term consumption of broad bean, especially unprocessed ones, can lead to hepatic lipid accumulation. To investigate how broad bean affected hepatic lipid metabolism and its underlying mechanisms, we conducted a multi-omics analysis of crisp grass carp (Ctenopharyngodon idellus C. et V) model with hepatic steatosis after feeding with single broad bean for 120 days. The glycolysis inhibition, increased de novo lipogenesis, abnormalities in lipid metabolism, and activation of oxidative stress were the key processes involved in broad bean-induced hepatic lipid accumulation. Disturbances in intestinal flora caused by damage to the intestinal barrier and increased lipopolysaccharide caused by broad bean promoted hepatic lipid accumulation. Reduction of antinutritional factors and balanced diet offer potential strategies to mitigate the liver damage caused by broad bean consumption. Overall, our findings provided a theoretical basis for the wide application of broad bean as animal feeds.

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蚕豆导致草鱼肝脏脂质代谢异常肠道微生物群-肝脏轴的启示
蚕豆(Vicia faba L.)作为一种可持续、廉价和多功能的植物性蛋白质来源,受到了食品和动物饲料行业的关注。然而,长期食用蚕豆,尤其是未经加工的蚕豆,会导致肝脏脂质积累。为了研究蚕豆对肝脏脂质代谢的影响及其内在机制,我们对脆性草鱼(Ctenopharyngodon idellus C. et V)模型进行了多组学分析。糖酵解抑制、新脂肪生成增加、脂质代谢异常和氧化应激激活是蚕豆诱导肝脂质积累的关键过程。肠道屏障受损导致肠道菌群失调,蚕豆引起的脂多糖增加促进了肝脏脂质积累。减少抗营养因素和平衡膳食为减轻食用蚕豆造成的肝损伤提供了潜在的策略。总之,我们的研究结果为蚕豆作为动物饲料的广泛应用提供了理论依据。
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