Clam Peptides Attenuated Adenine-Induced Chronic Kidney Disease by Improving Inflammation, Oxidative Stress, and Intestinal Flora Composition

IF 3.5 2区农林科学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Food Biochemistry Pub Date : 2024-03-04 DOI:10.1155/2024/5299378

Wenping Ren, Qiaoni You, Shanglong Wang, Zimin Liu, Shengcan Zou, Xiang Gao, Yuxi Wei

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Abstract

Previously, we have prepared clam peptides (RBPs) that exhibited potential antihypertension and kidney protective effects in SHR rats by fermentation of Ruditapes philippinarum with Bacillus natto. In this study, we established an adenine-induced chronic kidney disease (CKD) in SD rats and investigated the improvement effects of RBPs on CKD. The results showed that compared with the model group, 8 weeks gavage of RBPs restored the structure of the kidney and reduced serum levels of CKD-related biochemical indicators, including NGAL, CR, Ca, UA, TG, IP, L-FABP, BUN, CHO, and cystatin C (p < 0.05). RBPs treatment also reduced serum levels of MDA, IL-1β, TGF-β1, and TNF-α and increased those of CAT and T-AOC (p < 0.05). In addition, the results of intestinal microbiota analysis showed that RBPs improved the intestinal flora composition by downregulating the proportion of Firmicutes and Bacteroidetes, decreasing the relative abundance of Romboutsia, Ruminococcaceae_UCG-005, and Christensenellaceae_R-7_group and increasing that of Lactobacillus and Muribaculaceae (p < 0.05). The results of this study indicated that RBPs can also be used as bioactive substances in marine drugs or functional foods to alleviate CKD.

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蛤蜊肽通过改善炎症、氧化应激和肠道菌群组成减轻腺嘌呤诱发的慢性肾病

以前，我们曾通过纳豆芽孢杆菌发酵菲利蒲蛤（Ruditapes philippinarum）制备了蛤蜊肽（RBPs），该蛤蜊肽对 SHR 大鼠具有潜在的抗高血压和肾脏保护作用。本研究建立了腺嘌呤诱导的 SD 大鼠慢性肾脏病（CKD）模型，并研究了 RBPs 对 CKD 的改善作用。结果表明，与模型组相比，灌胃 RBPs 8 周可恢复肾脏结构，降低 CKD 相关生化指标的血清水平，包括 NGAL、CR、Ca、UA、TG、IP、L-FABP、BUN、CHO 和胱抑素 C（P<0.05）。RBPs治疗还降低了血清中MDA、IL-1β、TGF-β1和TNF-α的水平，提高了CAT和T-AOC的水平（P<0.05）。此外，肠道微生物群分析结果表明，RBPs 可改善肠道菌群组成，降低固着菌和类杆菌的比例，减少 Romboutsia、Ruminococcaceae_UCG-005 和 Christensenellaceae_R-7_group 的相对丰度，增加乳酸杆菌和 Muribaculaceae 的相对丰度（p<0.05）。该研究结果表明，RBPs 也可作为海洋药物或功能食品中的生物活性物质，用于缓解 CKD。

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来源期刊

Journal of Food Biochemistry 生物-生化与分子生物学

CiteScore

7.80

自引率

5.00%

发文量

488

审稿时长

3.6 months

期刊介绍： The Journal of Food Biochemistry publishes fully peer-reviewed original research and review papers on the effects of handling, storage, and processing on the biochemical aspects of food tissues, systems, and bioactive compounds in the diet. Researchers in food science, food technology, biochemistry, and nutrition, particularly based in academia and industry, will find much of great use and interest in the journal. Coverage includes: -Biochemistry of postharvest/postmortem and processing problems -Enzyme chemistry and technology -Membrane biology and chemistry -Cell biology -Biophysics -Genetic expression -Pharmacological properties of food ingredients with an emphasis on the content of bioactive ingredients in foods Examples of topics covered in recently-published papers on two topics of current wide interest, nutraceuticals/functional foods and postharvest/postmortem, include the following: -Bioactive compounds found in foods, such as chocolate and herbs, as they affect serum cholesterol, diabetes, hypertension, and heart disease -The mechanism of the ripening process in fruit -The biogenesis of flavor precursors in meat -How biochemical changes in farm-raised fish are affecting processing and edible quality