Melanoma-associated fibroblasts in tumor-promotion flammation and antitumor immunity: novel mechanisms and potential immunotherapeutic strategies.

IF 3.2 2区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Human molecular genetics Pub Date : 2024-06-21 DOI:10.1093/hmg/ddae056

Qiujun Zhou, Xiaoliang Jin, Ying Zhao, Yueping Wang, Maocan Tao, Yi Cao, Xiaohu Yin

{"title":"Melanoma-associated fibroblasts in tumor-promotion flammation and antitumor immunity: novel mechanisms and potential immunotherapeutic strategies.","authors":"Qiujun Zhou, Xiaoliang Jin, Ying Zhao, Yueping Wang, Maocan Tao, Yi Cao, Xiaohu Yin","doi":"10.1093/hmg/ddae056","DOIUrl":null,"url":null,"abstract":"<p><p>Melanoma, renowned for its aggressive behavior and resistance to conventional treatments, stands as a formidable challenge in the oncology landscape. The dynamic and complex interplay between cancer cells and the tumor microenvironment has gained significant attention, revealing Melanoma-Associated Fibroblasts (MAFs) as central players in disease progression. The heterogeneity of MAFs endows them with a dual role in melanoma. This exhaustive review seeks to not only shed light on the multifaceted roles of MAFs in orchestrating tumor-promoting inflammation but also to explore their involvement in antitumor immunity. By unraveling novel mechanisms underlying MAF functions, this review aims to provide a comprehensive understanding of their impact on melanoma development. Additionally, it delves into the potential of leveraging MAFs for innovative immunotherapeutic strategies, offering new avenues for enhancing treatment outcomes in the challenging realm of melanoma therapeutics.</p>","PeriodicalId":13070,"journal":{"name":"Human molecular genetics","volume":" ","pages":"1186-1193"},"PeriodicalIF":3.2000,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11190611/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human molecular genetics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1093/hmg/ddae056","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Melanoma, renowned for its aggressive behavior and resistance to conventional treatments, stands as a formidable challenge in the oncology landscape. The dynamic and complex interplay between cancer cells and the tumor microenvironment has gained significant attention, revealing Melanoma-Associated Fibroblasts (MAFs) as central players in disease progression. The heterogeneity of MAFs endows them with a dual role in melanoma. This exhaustive review seeks to not only shed light on the multifaceted roles of MAFs in orchestrating tumor-promoting inflammation but also to explore their involvement in antitumor immunity. By unraveling novel mechanisms underlying MAF functions, this review aims to provide a comprehensive understanding of their impact on melanoma development. Additionally, it delves into the potential of leveraging MAFs for innovative immunotherapeutic strategies, offering new avenues for enhancing treatment outcomes in the challenging realm of melanoma therapeutics.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

黑色素瘤相关成纤维细胞在肿瘤促进炎症和抗肿瘤免疫中的作用：新机制和潜在的免疫治疗策略。

黑色素瘤以其侵袭性和对常规治疗的抗药性而闻名，是肿瘤学领域的一项严峻挑战。癌细胞与肿瘤微环境之间动态而复杂的相互作用已引起人们的极大关注，揭示了黑色素瘤相关成纤维细胞（MAFs）在疾病进展中的核心作用。MAFs的异质性赋予了它们在黑色素瘤中的双重角色。这篇详尽的综述不仅试图揭示 MAFs 在协调肿瘤促发炎症中的多方面作用，还试图探讨它们在抗肿瘤免疫中的参与。通过揭示 MAF 功能的新机制，本综述旨在全面了解 MAF 对黑色素瘤发展的影响。此外，它还深入探讨了利用 MAFs 创新免疫治疗策略的潜力，为在黑色素瘤治疗这一充满挑战的领域提高治疗效果提供了新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Human molecular genetics 生物-生化与分子生物学

CiteScore

6.90

自引率

2.90%

发文量

294

审稿时长

2-4 weeks

期刊介绍： Human Molecular Genetics concentrates on full-length research papers covering a wide range of topics in all aspects of human molecular genetics. These include: the molecular basis of human genetic disease developmental genetics cancer genetics neurogenetics chromosome and genome structure and function therapy of genetic disease stem cells in human genetic disease and therapy, including the application of iPS cells genome-wide association studies mouse and other models of human diseases functional genomics computational genomics In addition, the journal also publishes research on other model systems for the analysis of genes, especially when there is an obvious relevance to human genetics.