Antigenic markers of T. gondii for chronic forms of toxoplasmosis in fertility age women

Abstract

Objective: This study aimed to assess the avidity of IgG antibodies against Toxoplasma gondii in fertile-aged women with a history of abortion. Using the recomLine Toxoplasma IgG Avidity kit, the research investigated the relationship between antibody avidity, T. gondii antigens (GRA1 and SAG1), and the number of abortions to enhance understanding of infection dynamics in this population. Methods : Forty (40)fertile aged women (18-37years)  with history of abortion and had  positive results of IgG Abs by minividus form October 2021 to April 2022 ,Kit of recomLine Toxoplasma IgG Avidity form Mikrogen /Germany,item No.11010, was used ,which is a qualitative in vitro test for the determination the avidity of IgG antibodies against Toxoplasma gondii in human serum or plasma. Results:  Phase II of toxoplasmosis was positive  of antibodies against different antigens detected by recomLine assay,  no  other significant relation was observed. Also, that there was no significant relation between the period of infection and avidity of IgG –Abs against different antigens  of T.gondii  detected by recomLine test. In addition The results showed that there was a significant relation  between of the number of abortions to GRA1-antigen (P=0.012) and SAG1-antigen (P=0.003) . Conclusion: There was a significant relation  between of the number of abortions to GRA1 and SAG1-antigens detected by recomLine assay ,where increase in the positive results with the increase in the number of abortions.