Non-immune hydrops fetalis: etiology, pathogenesis, features of diagnosis and treatment in the fetus and newborn

S. V. Dumova, H. A. Sarkisyan, O. Chugunova, I. D. Prokhorov, M. I. Nikolaeva, M. R. Globa, D. I. Nam, I. V. Zhuravleva, P. V. Shumilov
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Abstract

Non-immune hydrops fetalis is a polyetiological disease characterized by high perinatal mortality. The development of non-immune fetal hydrops is associated with diseases of the cardiovascular and lymphatic systems, genetic and chromosomal diseases, infectious agents and many other reasons. In this regard, there is no single approach to the treatment of this extremely dangerous pathological condition, which requires the joint work of specialists from different specialties: obstetricians-gynecologists, neonatologists, cardiologists, surgeons, hematologists and geneticists. This article provides a review of current literature data on the etiology, pathogenesis, clinical manifestations, treatment and outcomes of non-immune hydrops fetalis.
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非免疫性胎儿水肿:胎儿和新生儿的病因、发病机制、诊断和治疗特点
非免疫性胎儿水肿是一种多病因疾病,其特点是围产期死亡率高。非免疫性胎儿水肿的发生与心血管和淋巴系统疾病、遗传和染色体疾病、传染病病原体和其他许多原因有关。因此,治疗这种极其危险的病症没有单一的方法,需要来自不同专业的专家:妇产科医生、新生儿科医生、心脏科医生、外科医生、血液科医生和遗传学家的共同努力。本文综述了目前有关非免疫性胎儿水肿的病因、发病机制、临床表现、治疗和预后的文献资料。
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