Determination of consistency in pH of some commercial herbal formulations in Ghana

IF 2.2 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Journal of Herbal Medicine Pub Date : 2024-03-30 DOI:10.1016/j.hermed.2024.100876
Doris Kumadoh , Hilda Amekyeh , Mary-Ann Archer , Michael O. Kyene , Genevieve N. Yeboah , Henry Brew-Daniels , Ofosua Adi-Dako , Christina Osei-Asare , Emmanuel Adase , Alfred A. Appiah
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引用次数: 0

Abstract

Introduction

There are no strict pH standards for herbal formulations; however, pH can affect the characteristics of drugs and herbal formulations. In this study, the pHs of different herbal formulations produced in the past two batch years at the Centre for Plant Medicine Research (Mampong-Akuapem, Ghana) were analysed. We aimed to evaluate pH consistency among the formulations and suggest suitable pH ranges for the different product classes.

Methods

The formulations analysed were 17 decoctions, three ointments, and nine powders. Suitable ointment and powder samples were prepared before pH was measured, whereas decoctions were analysed directly.

Results

We found that 93.1% of the preparations had average pH < 7 over the two years. The pH values for the decoctions, ointments, and powders were 3.507−6.755, 5.153−5.700, and 5.413−10.719, respectively. Differences in pH over the two production years were not statistically significant for all the powder and ointment formulations as well as for majority of the decoctions (82.4%). This indicates pH consistency for approximately 90% of the products, possibly pointing to consistencies in plant material compositions, formulation conditions, and process parameters.

Conclusions

From our data and reported literature, we recommend that the labels of oral herbal preparations with pH < 5.5 should include an instruction to dilute the product before intake, or to drink water or rinse the mouth after intake to prevent enamel erosion. Decoctions may also be taken after food. Additionally, pH ranges of 4.6−7.0 and 4.0−6.0 may be suitable for rectal and topical herbal formulations, respectively.

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加纳某些商用草药配方 PH 值一致性的测定
导言:草药制剂没有严格的 pH 值标准,但 pH 值会影响药物和草药制剂的特性。本研究分析了植物药研究中心(加纳曼蓬-阿库阿佩姆)过去两个批次生产的不同草药配方的 pH 值。我们的目的是评估不同配方之间的 pH 值一致性,并为不同类别的产品提出合适的 pH 值范围。结果我们发现,93.1%的制剂在两年内的平均 pH 值为 7。煎剂、软膏和粉末的 pH 值分别为 3.507-6.755、5.153-5.700 和 5.413-10.719。所有粉剂和软膏以及大多数煎剂(82.4%)在两个生产年份的 pH 值差异均无统计学意义。结论根据我们的数据和已报道的文献,我们建议 pH 值为 5.5 的口服草药制剂的标签上应注明在服用前稀释产品,或在服用后喝水或漱口,以防止牙釉质受到侵蚀。煎剂也可在饭后服用。此外,4.6-7.0 和 4.0-6.0 的 pH 值范围可能分别适合直肠和局部草药配方。
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来源期刊
Journal of Herbal Medicine
Journal of Herbal Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
3.90
自引率
0.00%
发文量
94
期刊介绍: The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.
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