Antioxidant and α-Glucosidase inhibitory activity of various solvent fractions from Amaranthus viridis L., Amaranthus tricolor L., and Amaranthus spinosus L.

Journal of Medical pharmaceutical and allied sciences Pub Date : 2024-02-29 DOI:10.55522/jmpas.v13i1.5986

Bich Ngoc Giau Lu

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Abstract

Amaranthus tricolor L., Amaranthus spinosus L., and Amaranthus viridis L. are well-known for flavoring food products and traditional medicine. This study investigated the antioxidant and α-glucosidase inhibitory activity of various solvent fractions from the whole plant of A. tricolor, A. spinosus, and A. viridis in Vietnam. The total extract and solvent fractions of petroleum ether (PE), chloroform (CF), ethyl acetate (EA), n-butanol (B), and water (W) were tested for antioxidant activity using the DPPH assay and α-glucosidase inhibition. The results showed that the three species of Amaranthus had relatively low antioxidant activity, and the total extract of A. spinosus L. had the highest antioxidant activity with an IC50 value of 324.96 μg/mL. The EA fraction of A. tricolor had outstanding α-glucosidase inhibitory activity with an IC50 value of 95.94 μg/mL. It is recommended to continue isolation research to find active ingredients with α-glucosidase inhibition potential in the EA extract of A. tricolor. Additionally, an in vivo assay might be conducted to evaluate the activity and toxicity of this EA fraction.

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苋菜、三色苋和刺苋中各种溶剂馏分的抗氧化性和α-葡萄糖苷酶抑制活性

三色苋（Amaranthus tricolor L.）、旋花苋（Amaranthus spinosus L.）和病毒苋（Amaranthus viridis L.）是著名的调味食品和传统药物。本研究调查了越南三色苋、旋花苋和病毒苋全草中各种溶剂馏分的抗氧化和α-葡萄糖苷酶抑制活性。采用 DPPH 法和α-葡萄糖苷酶抑制法测试了总提取物和石油醚（PE）、氯仿（CF）、乙酸乙酯（EA）、正丁醇（B）和水（W）等溶剂馏分的抗氧化活性。结果表明，这三种马齿苋的抗氧化活性相对较低，其中 A. spinosus L. 的总提取物的抗氧化活性最高，IC50 值为 324.96 μg/mL。A.tricolor的EA部分具有突出的α-葡萄糖苷酶抑制活性，IC50值为95.94 μg/mL。建议继续进行分离研究，以寻找三色金莲花 EA 提取物中具有α-葡萄糖苷酶抑制潜力的活性成分。此外，还可以进行体内试验，以评估这种 EA 提取物的活性和毒性。

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Journal of Medical pharmaceutical and allied sciences

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