GC-MS Investigation of Unidentified Pharmaceutical ability of Indigenous herbaceous vine, Tinospora cordifolia’s fruits

Q3 Pharmacology, Toxicology and Pharmaceutics Research Journal of Pharmacy and Technology Pub Date : 2024-02-20 DOI:10.52711/0974-360x.2024.00095
Akhilraj B. C., Suresh J., R. K., Kumar M., G. R
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Abstract

As the majority of pharmaceutical businesses rely on medical plants for the synthesis of pharmaceutical chemicals, medicinal plants are of significant interest to researchers in the field of biotechnology. The majority of herbal remedies and the products that are derived from them are frequently made from unrefined plant extracts, which include a complex mixture of various phytochemical components (plant secondary metabolites). The chemical characteristics of these components vary greatly between species. An intriguing device for determining the concentration of various active constituents in plants utilised in the cosmetic, medicine, the agriculture or medical sectors is the GC-MS method employed for the assessment of the extracted samples. The entire plant methanol extract of Tinospora was used in this work to identify bioactive elements employing gas chromatography and mass spectrometry (GC-MS). The GC-MS results suggest several different chemicals, including (9E,11E)-Octadecadienoic acid , 9-Octadecenoic acid, (E)-, 9-Octadecenoic acid, Octadecanoic acid, .gamma.-Sitosterol, n-Hexadecanoic acid, 9-Octadecenoic acid (Z)-, 2,3-dihydroxypropyl ester, Methyl cis-4,7,10,13,16,19-Docosahexaenoate and 2-Hydrazino-2-imidazoline in the Tinospora methanolic extract. As a result, the bioactive compounds in the methanol extracts of this herb may have chemopreventive, antitumor, anti-microbial, antioxidants, and hypoglycaemic potential. This study's findings suggest that the existence of these phytochemicals as well as bioactive substances in Tinospora cordifolia makes it a potential new reservoir of medications.
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GC-MS 对本地草本藤本植物天竺葵果实中不明药用成分的研究
由于大多数制药企业都依赖药用植物来合成药物化学成分,因此药用植物引起了生物技术领域研究人员的极大兴趣。大多数草药及其衍生产品通常由未经提炼的植物提取物制成,其中包括各种植物化学成分(植物次生代谢物)的复杂混合物。这些成分的化学特性在不同物种之间差异很大。用于测定化妆品、医药、农业或医疗领域所用植物中各种有效成分浓度的一种有趣装置,就是对提取样品进行评估时采用的气相色谱-质谱(GC-MS)方法。在这项工作中,利用气相色谱和质谱法(GC-MS)对天南星全株甲醇提取物进行了生物活性元素鉴定。气相色谱-质谱(GC-MS)结果表明有几种不同的化学物质,包括 (9E,11E)-十八碳烯酸、9-十八碳烯酸、(E)-, 9-十八碳烯酸、十八酸、.gamma.-.γ.-谷甾醇、正十六烷酸、9-十八烯酸 (Z)-、2,3-二羟基丙酯、顺式-4,7,10,13,16,19-二十二碳六烯酸甲酯和 2-肼基-2-咪唑啉。因此,这种草药甲醇提取物中的生物活性化合物可能具有化学预防、抗肿瘤、抗微生物、抗氧化和降血糖的潜力。这项研究结果表明,Tinospora cordifolia 中存在的这些植物化学物质和生物活性物质使其成为一个潜在的新药物库。
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来源期刊
Research Journal of Pharmacy and Technology
Research Journal of Pharmacy and Technology Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
CiteScore
1.40
自引率
0.00%
发文量
0
期刊介绍: Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.
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