Anti-inflammatory activity of Codium elongatum on Carrageenan-induced paw edema in Wistar male rats

Abstract

Inflammation is the physiological defence system of the body to initiate the healing mechanism for tissue and eliminate injurious stimuli. In the present study, the anti-inflammatory activity of Codium elongatum was evaluated. Water extract (250 mg/kg, b.w.) and isolated polysaccharide (500 mg/kg, b.w.) are investigated in the carrageenan-induced rat paw edema model using phenylbutazone as a standard drug. Both water extract and isolated polysaccharide showed significant anti-inflammatory activity by blocking the cyclooxygenase 2 pathway. This is the first report to demonstrate the in-vivo anti-inflammatory activity of Codium elongatum.