{"title":"SIMPLE COST-EFFECTIVE STABILITY INDICATING METHOD FOR THE ESTIMATION OF AVANAFIL IN BULK OR FORMULATION BY RP-HPLC","authors":"Pankaj Kadwe, D. Basedia, V. Thakur, B. K. Dubey","doi":"10.38164/ajper/13.1.2024.39-49","DOIUrl":null,"url":null,"abstract":"This research presents a comprehensive analytical approach for the estimation of avanafil, a phosphodiesterase type 5 (PDE5) inhibitor used in the treatment of erectile dysfunction. The developed method utilizes Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) and focuses on stability indication, linearity, precision, and robustness. System suitability parameters, linearity, recovery studies, and forced degradation studies were conducted to validate the method's efficacy. The results indicate a reliable and cost-effective approach for the estimation of avanafil in both bulk and pharmaceutical formulations. The method demonstrates sensitivity, precision, and stability-indicating characteristics, making it a valuable tool for routine quality control processes in the pharmaceutical industry.","PeriodicalId":8533,"journal":{"name":"Asian Journal of Pharmaceutical Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Pharmaceutical Education and Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.38164/ajper/13.1.2024.39-49","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
This research presents a comprehensive analytical approach for the estimation of avanafil, a phosphodiesterase type 5 (PDE5) inhibitor used in the treatment of erectile dysfunction. The developed method utilizes Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) and focuses on stability indication, linearity, precision, and robustness. System suitability parameters, linearity, recovery studies, and forced degradation studies were conducted to validate the method's efficacy. The results indicate a reliable and cost-effective approach for the estimation of avanafil in both bulk and pharmaceutical formulations. The method demonstrates sensitivity, precision, and stability-indicating characteristics, making it a valuable tool for routine quality control processes in the pharmaceutical industry.
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