Pub Date : 2024-01-15DOI: 10.38164/ajper/13.1.2024.27-38
Shubham K. Chaudhari, Pankaj M. Pimpalshende, S. Kosalge
Diabetes is a long-term metabolic disease marked by the body's incapacity to control blood sugar levels. The prevalence of diabetes has increased significantly due to dietary and lifestyle choices. Novel therapeutic approaches have been investigated to control diabetes and mitigate the dangers related to current medication. Advanced microspheres have been created by certain researchers recently, either for the delivery of insulin and anti-diabetic medications or for diagnostic use. The creation of controlled or sustained delivery products with a quick start of action and enhanced bioavailability is made possible by these microspheres. The purpose of this study is to present an overview of diabetes, contemporary treatments, innovative drug delivery methods specifically, microballoons and previously developed microballoons for anti-diabetic medications. There is much promise for incorporating novel approaches in the diagnosis and treatment of diabetes with microballoons. There may still be issues with these approaches' scalability and practical applications that need to be resolved.
{"title":"MICROBALLOONS: A NOVEL APPROACH TO MITIGATE DIABETES","authors":"Shubham K. Chaudhari, Pankaj M. Pimpalshende, S. Kosalge","doi":"10.38164/ajper/13.1.2024.27-38","DOIUrl":"https://doi.org/10.38164/ajper/13.1.2024.27-38","url":null,"abstract":"Diabetes is a long-term metabolic disease marked by the body's incapacity to control blood sugar levels. The prevalence of diabetes has increased significantly due to dietary and lifestyle choices. Novel therapeutic approaches have been investigated to control diabetes and mitigate the dangers related to current medication. Advanced microspheres have been created by certain researchers recently, either for the delivery of insulin and anti-diabetic medications or for diagnostic use. The creation of controlled or sustained delivery products with a quick start of action and enhanced bioavailability is made possible by these microspheres. The purpose of this study is to present an overview of diabetes, contemporary treatments, innovative drug delivery methods specifically, microballoons and previously developed microballoons for anti-diabetic medications. There is much promise for incorporating novel approaches in the diagnosis and treatment of diabetes with microballoons. There may still be issues with these approaches' scalability and practical applications that need to be resolved.","PeriodicalId":8533,"journal":{"name":"Asian Journal of Pharmaceutical Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15DOI: 10.38164/ajper/13.1.2024.15-26
Megha Ramesh Tonge, Pankaj M. Pimpalshende, S. Kosalge
The pursuit of enhanced efficacy and tailored delivery has motivated the assessment of medication delivery methods. Conventional methods have established the groundwork, but progress is necessary to surmount their constraints. This thorough analysis delves into the novel field of invasomes, a kind of vesicular carriers intended to improve medication delivery across biological barriers. An outline of conventional medication administration methods is given at the outset of the paper, highlighting the necessity of cutting edge techniques. It introduces vesicular carriers, focusing on the well-established liposomes, and traces the evolution towards invasomes. The distinctive features of invasomes specifically, their invasiveness are emphasized, tackling the crucial difficulty of attaining therapeutic concentrations at target locations. The dissection of the structure and content of invasomes highlights the importance of surfactants, lipid composition, and other components that contribute to their increased penetrating capacities. A particular focus is on the malleable character of invasomes, which allows them to effectively pass through biological membranes and narrow spaces. There is discussion of several techniques for preparing invasomes, such as freeze drying, ether injection, thin film hydration, and reverse phase evaporation. Researchers can choose the best strategies based on specific requirements by comparing various methods and seeing how they affect invasome features. The review explores various analytical techniques for characterizing invasomes, such as high-performance liquid chromatography, differential scanning calorimetry, particle size, spectroscopy, and microscopy. The successful use of these strategies in medication delivery can be attributed to their insights into invasive characteristics. Success stories in dermatology, cancer therapy, ocular drug delivery, infectious diseases, vaccines, neurological disorders, and cardiovascular therapies are highlighted as the broad range of therapeutic areas in which invasomes are applied are examined. The encouraging results demonstrate how invasomes have the potential to completely transform drug delivery in a variety of medical fields. There is a discussion of the present state and potential future developments of invadesomes in regulatory approval procedures.
{"title":"ADVANCEMENTS IN INVASOMES FOR ENHANCED DRUG DELIVERY: A COMPREHENSIVE REVIEW","authors":"Megha Ramesh Tonge, Pankaj M. Pimpalshende, S. Kosalge","doi":"10.38164/ajper/13.1.2024.15-26","DOIUrl":"https://doi.org/10.38164/ajper/13.1.2024.15-26","url":null,"abstract":"The pursuit of enhanced efficacy and tailored delivery has motivated the assessment of medication delivery methods. Conventional methods have established the groundwork, but progress is necessary to surmount their constraints. This thorough analysis delves into the novel field of invasomes, a kind of vesicular carriers intended to improve medication delivery across biological barriers. An outline of conventional medication administration methods is given at the outset of the paper, highlighting the necessity of cutting edge techniques. It introduces vesicular carriers, focusing on the well-established liposomes, and traces the evolution towards invasomes. The distinctive features of invasomes specifically, their invasiveness are emphasized, tackling the crucial difficulty of attaining therapeutic concentrations at target locations. The dissection of the structure and content of invasomes highlights the importance of surfactants, lipid composition, and other components that contribute to their increased penetrating capacities. A particular focus is on the malleable character of invasomes, which allows them to effectively pass through biological membranes and narrow spaces. There is discussion of several techniques for preparing invasomes, such as freeze drying, ether injection, thin film hydration, and reverse phase evaporation. Researchers can choose the best strategies based on specific requirements by comparing various methods and seeing how they affect invasome features. The review explores various analytical techniques for characterizing invasomes, such as high-performance liquid chromatography, differential scanning calorimetry, particle size, spectroscopy, and microscopy. The successful use of these strategies in medication delivery can be attributed to their insights into invasive characteristics. Success stories in dermatology, cancer therapy, ocular drug delivery, infectious diseases, vaccines, neurological disorders, and cardiovascular therapies are highlighted as the broad range of therapeutic areas in which invasomes are applied are examined. The encouraging results demonstrate how invasomes have the potential to completely transform drug delivery in a variety of medical fields. There is a discussion of the present state and potential future developments of invadesomes in regulatory approval procedures.","PeriodicalId":8533,"journal":{"name":"Asian Journal of Pharmaceutical Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15DOI: 10.38164/ajper/13.1.2024.39-49
Pankaj Kadwe, D. Basedia, V. Thakur, B. K. Dubey
This research presents a comprehensive analytical approach for the estimation of avanafil, a phosphodiesterase type 5 (PDE5) inhibitor used in the treatment of erectile dysfunction. The developed method utilizes Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) and focuses on stability indication, linearity, precision, and robustness. System suitability parameters, linearity, recovery studies, and forced degradation studies were conducted to validate the method's efficacy. The results indicate a reliable and cost-effective approach for the estimation of avanafil in both bulk and pharmaceutical formulations. The method demonstrates sensitivity, precision, and stability-indicating characteristics, making it a valuable tool for routine quality control processes in the pharmaceutical industry.
{"title":"SIMPLE COST-EFFECTIVE STABILITY INDICATING METHOD FOR THE ESTIMATION OF AVANAFIL IN BULK OR FORMULATION BY RP-HPLC","authors":"Pankaj Kadwe, D. Basedia, V. Thakur, B. K. Dubey","doi":"10.38164/ajper/13.1.2024.39-49","DOIUrl":"https://doi.org/10.38164/ajper/13.1.2024.39-49","url":null,"abstract":"This research presents a comprehensive analytical approach for the estimation of avanafil, a phosphodiesterase type 5 (PDE5) inhibitor used in the treatment of erectile dysfunction. The developed method utilizes Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) and focuses on stability indication, linearity, precision, and robustness. System suitability parameters, linearity, recovery studies, and forced degradation studies were conducted to validate the method's efficacy. The results indicate a reliable and cost-effective approach for the estimation of avanafil in both bulk and pharmaceutical formulations. The method demonstrates sensitivity, precision, and stability-indicating characteristics, making it a valuable tool for routine quality control processes in the pharmaceutical industry.","PeriodicalId":8533,"journal":{"name":"Asian Journal of Pharmaceutical Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15DOI: 10.38164/ajper/13.1.2024.1-14
Sakshi Chandrakant Wankhede, Pankaj M. Pimpalshende, S. Kosalge
For patients receiving chemotherapy and radiation therapy, nausea and vomiting are serious issues. Moreover, post-operative nausea and vomiting are common side effects. Postoperative nausea and vomiting (PONV) is thought to occur in 25–30% of cases. Furthermore, oral thin films provide accurate and adaptable dosing. Oral films are made easier and more convenient by these qualities, which also have positive medicinal effects. Drugs are rapidly absorbed in the mouth when administered via buccal or sublingual film delivery. This reduces exposure to the gastrointestinal system and addresses issues that are frequently related to tablets and capsules, including first-pass metabolism, gastrointestinal adverse effects, and sluggish or restricted absorption in the GI tract. Consequently, buccal or sublingual films might provide increased patient compliance, decreased adverse effects, and higher absorption. This article provides a thorough understanding of emesis, including its causes, treatments for emesis, innovative oral thin-film drug delivery, its properties, methods for fabrication and assessment, and, finally, previously published research on antiemetic oral thin-film.
{"title":"FAST DISSOLVING ORAL FILM: A BOON FOR PATIENTS SUFFERING WITH NAUSEA AND VOMITING","authors":"Sakshi Chandrakant Wankhede, Pankaj M. Pimpalshende, S. Kosalge","doi":"10.38164/ajper/13.1.2024.1-14","DOIUrl":"https://doi.org/10.38164/ajper/13.1.2024.1-14","url":null,"abstract":"For patients receiving chemotherapy and radiation therapy, nausea and vomiting are serious issues. Moreover, post-operative nausea and vomiting are common side effects. Postoperative nausea and vomiting (PONV) is thought to occur in 25–30% of cases. Furthermore, oral thin films provide accurate and adaptable dosing. Oral films are made easier and more convenient by these qualities, which also have positive medicinal effects. Drugs are rapidly absorbed in the mouth when administered via buccal or sublingual film delivery. This reduces exposure to the gastrointestinal system and addresses issues that are frequently related to tablets and capsules, including first-pass metabolism, gastrointestinal adverse effects, and sluggish or restricted absorption in the GI tract. Consequently, buccal or sublingual films might provide increased patient compliance, decreased adverse effects, and higher absorption. This article provides a thorough understanding of emesis, including its causes, treatments for emesis, innovative oral thin-film drug delivery, its properties, methods for fabrication and assessment, and, finally, previously published research on antiemetic oral thin-film.","PeriodicalId":8533,"journal":{"name":"Asian Journal of Pharmaceutical Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140506854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15DOI: 10.38164/ajper/13.1.2024.50-65
M. Hudgi, S. Santh, A. Awasthi, B. Mantripragada, D. Pingili
This research article explores the influence of fruit juices on the efficiency of the biginelli reaction, a versatile multicomponent synthesis for diverse dihydropyrimidinones. A comparative analysis of fruit juices as green reaction media assessed their impact on reaction rates, yields, and selectivity. Biginelli reactions were carried out in fruit juices using equimolar mixture of thiourea /urea, ethyl acetoacetate and aromatic aldehyde under microwave irradiation. The reaction progressed within minutes, monitored by TLC
{"title":"BIGINELLI REACTION: COMPARATIVE STUDY OF FRUIT JUICES, OPTIMIZATION STRATEGIES, IN-SILICO ANALYSIS AND PHARMACOLOGICAL ACTIVITY","authors":"M. Hudgi, S. Santh, A. Awasthi, B. Mantripragada, D. Pingili","doi":"10.38164/ajper/13.1.2024.50-65","DOIUrl":"https://doi.org/10.38164/ajper/13.1.2024.50-65","url":null,"abstract":"This research article explores the influence of fruit juices on the efficiency of the biginelli reaction, a versatile multicomponent synthesis for diverse dihydropyrimidinones. A comparative analysis of fruit juices as green reaction media assessed their impact on reaction rates, yields, and selectivity. Biginelli reactions were carried out in fruit juices using equimolar mixture of thiourea /urea, ethyl acetoacetate and aromatic aldehyde under microwave irradiation. The reaction progressed within minutes, monitored by TLC","PeriodicalId":8533,"journal":{"name":"Asian Journal of Pharmaceutical Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140506781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-10DOI: 10.38164/ajper/12.1s.2023.1-33
Dr. Ambedkar Institute of Pharmaceutical Science
{"title":"\"RECENT ADVANCEMENT IN PHARMACEUTICAL RESEARCH AND BIOMEDICINES \"","authors":"Dr. Ambedkar Institute of Pharmaceutical Science","doi":"10.38164/ajper/12.1s.2023.1-33","DOIUrl":"https://doi.org/10.38164/ajper/12.1s.2023.1-33","url":null,"abstract":"","PeriodicalId":8533,"journal":{"name":"Asian Journal of Pharmaceutical Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81429857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A REVIEW ON POTENTIAL OF ARTIFICIAL INTELLIGENCE IN DIAGNOSIS, DRUG DISCOVERY AND VACCINE DEVELOPMENT AGAINST COVID-19","authors":"Muskan Yadav, Anupriya Jain, Nandini Kurmi, Pushpendra Kumar Khangar","doi":"10.38164/ajper/11.1.2022.1-22","DOIUrl":"https://doi.org/10.38164/ajper/11.1.2022.1-22","url":null,"abstract":"","PeriodicalId":8533,"journal":{"name":"Asian Journal of Pharmaceutical Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75610766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-10DOI: 10.38164/ajper/11.1.2022.46-54
Nimisha Singh, Shailendra Bindaiya, S. Lariya
{"title":"FORMULATION, DEVELOPMENT AND EVALUATION OF EMULGEL OF MOMETASONE FUROATE FOR EFFECTIVE TREATMENT OF TOPICAL DISEASE","authors":"Nimisha Singh, Shailendra Bindaiya, S. Lariya","doi":"10.38164/ajper/11.1.2022.46-54","DOIUrl":"https://doi.org/10.38164/ajper/11.1.2022.46-54","url":null,"abstract":"","PeriodicalId":8533,"journal":{"name":"Asian Journal of Pharmaceutical Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73383145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-10DOI: 10.38164/ajper/11.1.2022.99-108
P. Pandey, Shailendra Bindaiya, S. Lariya
{"title":"FORMULATION, DEVELOPMENT AND EVALUATION OF SILVER NANOPARTICLES OF BLEPHARIS EDULIS FOR THE TREATMENT OF CANDIDIASIS","authors":"P. Pandey, Shailendra Bindaiya, S. Lariya","doi":"10.38164/ajper/11.1.2022.99-108","DOIUrl":"https://doi.org/10.38164/ajper/11.1.2022.99-108","url":null,"abstract":"","PeriodicalId":8533,"journal":{"name":"Asian Journal of Pharmaceutical Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74850755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-10DOI: 10.38164/ajper/11.1.2022.79-89
V. Dhote, Kanika Dhote, S. Jain, Deepti Jain
{"title":"FORMULATION & EVALUATION OF ETHOSOMAL PATCH FOR DELIVERY OF METHOXSALENE","authors":"V. Dhote, Kanika Dhote, S. Jain, Deepti Jain","doi":"10.38164/ajper/11.1.2022.79-89","DOIUrl":"https://doi.org/10.38164/ajper/11.1.2022.79-89","url":null,"abstract":"","PeriodicalId":8533,"journal":{"name":"Asian Journal of Pharmaceutical Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72938231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：