Oral pH triggered colon-specific ketoprofen loaded microspheres for the better management of early morning symptoms associated with rheumatoid arthritis. Part I: Optimization, in-vitro, and ex-vivo characterization

IF 1.9 4区 化学 Q4 CHEMISTRY, PHYSICAL Journal of Dispersion Science and Technology Pub Date : 2024-04-09 DOI:10.1080/01932691.2024.2338359
Krishna Sanka, Prabhakar Reddy Veerareddy, Rajeswara Rao Pragada
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Abstract

The primary goal of this research was to investigate pH-triggered colon-specific ketoprofen-loaded microspheres (C-SKLM) using Eudragit S-100 as a pH-dependent polymer. The formulation was optimize...
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口服 pH 触发的结肠特异性酮洛芬负载微球,用于更好地治疗类风湿性关节炎相关的清晨症状。第一部分:优化、体外和体内表征
这项研究的主要目的是利用Eudragit S-100作为pH值依赖性聚合物,研究pH值触发的结肠特异性酮洛芬负载微球(C-SKLM)。对配方进行了优化...
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来源期刊
CiteScore
5.00
自引率
4.50%
发文量
140
审稿时长
1.1 months
期刊介绍: Journal of Dispersion Science and Technology is an international journal covering fundamental and applied aspects of dispersions, emulsions, vesicles, microemulsions, liquid crystals, particle suspensions and sol-gel processes. Fundamental areas that are covered include new surfactants, polymers and indigenous stabilizers; surfactant and polymer association as well as phase equilibria in systems water and oil; surfactant and polymer films, monolayers and interfacial films; adsorption and desorption onto solid surfaces; stability and destabilization of dispersions, emulsions and particle suspensions; collodal templates and sol-gel processing. Industrial applications cover chemicals, crude oils, food, pharmaceuticals, agriculture, nanotechnology, and soft condensed materials.
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