Correlation of Diabetes Related Factors with Vitamin D and Immunological Parameters in T2DM Kashmiri Population.

IF 1.5 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Indian Journal of Clinical Biochemistry Pub Date : 2024-10-01 Epub Date: 2023-07-28 DOI:10.1007/s12291-023-01144-1
Najeebul Tarfeen, Khair Ul Nisa, Shariq Rashid Masoodi, Humaira Bhat, Saba Wani, Bashir Ahmad Ganai
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Abstract

In this study, the role of inflammatory biomarkers and vitamin D in Type 2 diabetes mellitus (T2DM) and their correlation with diabetes related factors (HbA1c, FPG, and insulin) was analysed. In this study, Kashmiri patients with T2DM and healthy individuals were considered as cases (n = 100) and controls (n = 100) respectively. Blood samples from both groups were collected, inflammatory biomarkers (TNF-α, CRP), as well as serum vitamin D levels, were estimated by ELISA. From our results it was revealed that patients with T2DM had significantly lower serum vitamin D levels than control groups (p<0.05). Pro-inflammatory cytokine levels, including TNF-α and CRP, were seen to be elevated reaching a level of statistical significance (p<0.05). On correlating the HbA1c, FPG and insulin with TNF-α, CRP and vitamin D, significant positive correlation (p<0.05) was found between TNF-α and CRP with HbA1c and FPG in patients, non-significant positive correlation (p>0.05) was observed between insulin with TNF-α, and vitamin D and weak negative correlation with CRP in case study group. On correlating the impact of vitamin D on HbA1c and FPG levels, non-significant weak negative correlation was observed in patient group than controls, indicating that patients with lower vitamin D levels have higher HbA1c, showing that lower vitamin D have some role in etiology of T2DM.

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克什米尔 T2DM 人口中糖尿病相关因素与维生素 D 和免疫参数的相关性。
在这项研究中,分析了炎症生物标志物和维生素 D 在 2 型糖尿病(T2DM)中的作用及其与糖尿病相关因素(HbA1c、FPG 和胰岛素)的相关性。在这项研究中,克什米尔 T2DM 患者和健康人分别被视为病例(100 人)和对照组(100 人)。研究人员采集了两组患者的血液样本,并通过 ELISA 方法估算了炎症生物标志物(TNF-α、CRP)和血清维生素 D 水平。结果显示,T2DM 患者的血清维生素 D 水平明显低于对照组(ppp>0.05),在病例研究组中,胰岛素与 TNF-α 和维生素 D 之间呈负相关,与 CRP 呈弱相关。在维生素 D 对 HbA1c 和 FPG 水平影响的相关性方面,观察到患者组比对照组存在非显著的弱负相关,表明维生素 D 水平较低的患者 HbA1c 较高,这说明维生素 D 水平较低在 T2DM 的病因中起一定作用。
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来源期刊
Indian Journal of Clinical Biochemistry
Indian Journal of Clinical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
4.50
自引率
4.80%
发文量
74
期刊介绍: The primary mission of the journal is to promote improvement in the health and well-being of community through the development and practice of clinical biochemistry and dissemination of knowledge and recent advances in this discipline among professionals, diagnostics industry, government and non-government organizations. Indian Journal of Clinical Biochemistry (IJCB) publishes peer reviewed articles that contribute to the existing knowledge in all fields of Clinical biochemistry, either experimental or theoretical, particularly deal with the applications of biochemistry, molecular biology, genetics, biotechnology, and immunology to the diagnosis, treatment, monitoring and prevention of human diseases. The articles published also include those covering the analytical and molecular diagnostic techniques, instrumentation, data processing, quality assurance and accreditation aspects of the clinical investigations in which chemistry has played a major role, or laboratory animal studies with biochemical and clinical relevance.
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