Najeebul Tarfeen, Khair Ul Nisa, Shariq Rashid Masoodi, Humaira Bhat, Saba Wani, Bashir Ahmad Ganai
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引用次数: 0
Abstract
In this study, the role of inflammatory biomarkers and vitamin D in Type 2 diabetes mellitus (T2DM) and their correlation with diabetes related factors (HbA1c, FPG, and insulin) was analysed. In this study, Kashmiri patients with T2DM and healthy individuals were considered as cases (n = 100) and controls (n = 100) respectively. Blood samples from both groups were collected, inflammatory biomarkers (TNF-α, CRP), as well as serum vitamin D levels, were estimated by ELISA. From our results it was revealed that patients with T2DM had significantly lower serum vitamin D levels than control groups (p<0.05). Pro-inflammatory cytokine levels, including TNF-α and CRP, were seen to be elevated reaching a level of statistical significance (p<0.05). On correlating the HbA1c, FPG and insulin with TNF-α, CRP and vitamin D, significant positive correlation (p<0.05) was found between TNF-α and CRP with HbA1c and FPG in patients, non-significant positive correlation (p>0.05) was observed between insulin with TNF-α, and vitamin D and weak negative correlation with CRP in case study group. On correlating the impact of vitamin D on HbA1c and FPG levels, non-significant weak negative correlation was observed in patient group than controls, indicating that patients with lower vitamin D levels have higher HbA1c, showing that lower vitamin D have some role in etiology of T2DM.
期刊介绍:
Journal of Dispersion Science and Technology is an international journal covering fundamental and applied aspects of dispersions, emulsions, vesicles, microemulsions, liquid crystals, particle suspensions and sol-gel processes. Fundamental areas that are covered include new surfactants, polymers and indigenous stabilizers; surfactant and polymer association as well as phase equilibria in systems water and oil; surfactant and polymer films, monolayers and interfacial films; adsorption and desorption onto solid surfaces; stability and destabilization of dispersions, emulsions and particle suspensions; collodal templates and sol-gel processing. Industrial applications cover chemicals, crude oils, food, pharmaceuticals, agriculture, nanotechnology, and soft condensed materials.