Allergic reaction of poly-ether-ether-ketone versus titanium implants: A posttest-only control group design experimental study using a rabbit model

IF 3.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Clinical Implant Dentistry and Related Research Pub Date : 2024-04-04 DOI:10.1111/cid.13323

Tamer Hamed Hassan, Nabeel Ayappali Kalluvalappil

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Abstract

Purpose

The aim of this study was to determine clinically and genetically the allergic effects of titanium and poly-ether-ether-ketone (PEEK) implants following loading in rabbit tibias.

Materials and methods

This study included 18 white New Zealand male rabbits (n = 18) divided evenly into three groups: control, titanium (Ti), and PEEK (P). Clinically, the allergenic effect of titanium and PEEK was investigated by detecting the effect on lymph nodes. Furthermore, RT-PCR and ELISA were used to detect the expression of certain genes IL-6, TNF-α, OPG, RANKL, and RUNX-2 through both types of implants.

Results

Our findings demonstrated that titanium implants induced enlarged lymph nodes, which PEEK did not. Overall, RT-PCR and ELISA techniques revealed that Ti implants had higher expression of the inflammatory genes IL-6 and TNF-α. Ti had the highest expression in OPG findings, while PEEK had the lowest. RANKL expression was highest in the control group and lowest in the PEEK group. RUNX-2 is the highest for the control group and the lowest for the titanium group.

Conclusion

Although titanium implants elicited greater allergy responses than PEEK implants, titanium has the highest expression of bone formation genes and the lowest expression of bone resorption genes, making it preferable to PEEK.

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聚醚醚酮与钛植入物的过敏反应：以兔子为模型进行的纯试验后对照组设计实验研究

本研究的目的是从临床和遗传学角度确定钛和聚醚醚酮（PEEK）植入物在兔胫骨装载后的过敏效应。材料和方法本研究包括 18 只白色新西兰雄兔（n = 18），平均分为三组：对照组、钛组（Ti）和 PEEK 组（P）。在临床上，通过检测对淋巴结的影响来研究钛和 PEEK 的过敏效应。此外，还使用 RT-PCR 和 ELISA 检测了两种植入物中某些基因 IL-6、TNF-α、OPG、RANKL 和 RUNX-2 的表达情况。总体而言，RT-PCR 和 ELISA 技术表明，钛种植体的炎症基因 IL-6 和 TNF-α 表达较高。在 OPG 的研究结果中，钛的表达量最高，而 PEEK 的表达量最低。对照组的 RANKL 表达最高，而 PEEK 组最低。RUNX-2在对照组中最高，而在钛组中最低。结论虽然钛种植体比 PEEK 种植体引起的过敏反应更大，但钛在骨形成基因中的表达量最高，而在骨吸收基因中的表达量最低，因此钛比 PEEK 更受青睐。

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来源期刊

Clinical Implant Dentistry and Related Research 医学-牙科与口腔外科

CiteScore

6.00

自引率

13.90%

发文量

103

审稿时长

4-8 weeks

期刊介绍： The goal of Clinical Implant Dentistry and Related Research is to advance the scientific and technical aspects relating to dental implants and related scientific subjects. Dissemination of new and evolving information related to dental implants and the related science is the primary goal of our journal. The range of topics covered by the journals will include but be not limited to: New scientific developments relating to bone Implant surfaces and their relationship to the surrounding tissues Computer aided implant designs Computer aided prosthetic designs Immediate implant loading Immediate implant placement Materials relating to bone induction and conduction New surgical methods relating to implant placement New materials and methods relating to implant restorations Methods for determining implant stability A primary focus of the journal is publication of evidenced based articles evaluating to new dental implants, techniques and multicenter studies evaluating these treatments. In addition basic science research relating to wound healing and osseointegration will be an important focus for the journal.