Manufacturing of a Novel Sensor Based CuO@Graphene Catalyst for Voltammetric Detection of Prednisolone as an Important Doping Agent in Sport

IF 2.8 3区化学 Q2 CHEMISTRY, APPLIED Topics in Catalysis Pub Date : 2024-04-01 DOI:10.1007/s11244-024-01931-x

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Abstract

Selective and sensitive measurement of Prednisolone is vital for its routine analysis in pharmaceutical formulations and doping control in sports. In present research, an effective sensing platform for analysis of prednisolone in body fluids based on CuO@graphene nano-sized (Gr–CuO) catalyst was suggested. The electrochemical sensor was fabricated by deposition of the Gr–CuO on the GCE that provides a remarkably improved sensitivity for the square wave voltammetry detection of prednisolone drug. The uniform distribution of nano-sized CuO NPs led to superior electrocatalyst property, thereby maximizing the prednisolone determination abilities of the suggested sensor. The presented sensing strategy illustrates the acceptable linear response in the range of concentrations of 0.01–25 µM with a low detection limit of 0.008 µM owing to synergetic effect of Gr nanosheets and CuO NPs. The RSD value for prednisolone measurement using seven various GCEs was estimated as 3.4%. The anti-interference investigations confirmed that the different common biological interference such as glucose, dopamine, uric acid, ascorbic aide, xanthine and hypoxanthine did not affect the quantitative analysis of prednisolone. The validity of the Gr–CuO/GCE showed that the accurate detection of prednisolone in the body fluids of some athletes.

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制造用于伏安法检测体育运动中重要兴奋剂泼尼松龙的基于 CuO@Graphene 催化剂的新型传感器

摘要选择性和灵敏度测量泼尼松龙对于药物制剂中的常规分析和体育运动中的兴奋剂控制至关重要。本研究提出了一种基于 CuO@graphene 纳米尺寸（Gr-CuO）催化剂的分析体液中泼尼松龙的有效传感平台。该电化学传感器是通过在 GCE 上沉积 Gr-CuO 制成的，可显著提高方波伏安法检测泼尼松龙药物的灵敏度。纳米级 CuO NPs 的均匀分布带来了卓越的电催化剂特性，从而最大限度地提高了所建议传感器的泼尼松龙测定能力。由于 Gr 纳米片和 CuO NPs 的协同作用，所提出的传感策略在 0.01-25 µM 的浓度范围内具有可接受的线性响应，检测限低至 0.008 µM。使用七种不同的 GCE 测量泼尼松龙的 RSD 值估计为 3.4%。抗干扰研究证实，葡萄糖、多巴胺、尿酸、抗坏血酸、黄嘌呤和次黄嘌呤等常见生物干扰均不影响泼尼松龙的定量分析。Gr-CuO/GCE的有效性表明，它能准确检测出一些运动员体液中的泼尼松龙。

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来源期刊

Topics in Catalysis 化学-物理化学

CiteScore

5.70

自引率

5.60%

发文量

197

审稿时长

2 months

期刊介绍： Topics in Catalysis publishes topical collections in all fields of catalysis which are composed only of invited articles from leading authors. The journal documents today’s emerging and critical trends in all branches of catalysis. Each themed issue is organized by renowned Guest Editors in collaboration with the Editors-in-Chief. Proposals for new topics are welcome and should be submitted directly to the Editors-in-Chief. The publication of individual uninvited original research articles can be sent to our sister journal Catalysis Letters. This journal aims for rapid publication of high-impact original research articles in all fields of both applied and theoretical catalysis, including heterogeneous, homogeneous and biocatalysis.