Effect of a low-carbohydrate diet on pain and quality of life in female patients with lipedema: a randomized controlled trial

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Obesity Pub Date : 2024-04-16 DOI:10.1002/oby.24026

Julianne Lundanes, Frida Sandnes, Kari Hanne Gjeilo, Patrik Hansson, Sissel Salater, Catia Martins, Siren Nymo

{"title":"Effect of a low-carbohydrate diet on pain and quality of life in female patients with lipedema: a randomized controlled trial","authors":"Julianne Lundanes, Frida Sandnes, Kari Hanne Gjeilo, Patrik Hansson, Sissel Salater, Catia Martins, Siren Nymo","doi":"10.1002/oby.24026","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>The primary objective of this study was to evaluate the effect of a low-carbohydrate diet (LCD) compared with a control diet on pain in female patients with lipedema. The secondary objectives were to compare the impact of the two diets on quality of life (QoL) and investigate potential associations of changes in pain with changes in body weight, body composition, and ketosis.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Adult female patients with lipedema and obesity were randomized to either the LCD or control diet (energy prescription: 1200 kcal/day) for 8 weeks. Body weight and body composition, pain (Brief Pain Inventory measured pain), and QoL (RAND 36-Item Health Survey [RAND-36], Impact of Weight on Quality of Life [IWQOL]-Lite, and Lymphoedema Quality of Life [LYMQOL]) were measured at baseline and at postintervention.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A total of 70 female patients (age, mean [SD], 47 [11] years; BMI 37 [5] kg/m<sup>2</sup>) were included. The LCD group had greater weight loss (−2.8 kg; 95% CI: −4.1 to −1.0; <i>p</i> < 0.001) and larger reduction in pain now (−1.1; 95% CI: −1.9 to −0.3; <i>p</i> = 0.009) compared with the control group. No association was found between changes in pain now and weight loss. Both groups experienced improvements in several QoL dimensions.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Diet-induced weight loss in women with lipedema can improve QoL. An energy-restricted LCD seems to be superior to a standard control diet in reducing pain.</p>\n </section>\n </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24026","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/oby.24026","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

The primary objective of this study was to evaluate the effect of a low-carbohydrate diet (LCD) compared with a control diet on pain in female patients with lipedema. The secondary objectives were to compare the impact of the two diets on quality of life (QoL) and investigate potential associations of changes in pain with changes in body weight, body composition, and ketosis.

Methods

Adult female patients with lipedema and obesity were randomized to either the LCD or control diet (energy prescription: 1200 kcal/day) for 8 weeks. Body weight and body composition, pain (Brief Pain Inventory measured pain), and QoL (RAND 36-Item Health Survey [RAND-36], Impact of Weight on Quality of Life [IWQOL]-Lite, and Lymphoedema Quality of Life [LYMQOL]) were measured at baseline and at postintervention.

Results

A total of 70 female patients (age, mean [SD], 47 [11] years; BMI 37 [5] kg/m²) were included. The LCD group had greater weight loss (−2.8 kg; 95% CI: −4.1 to −1.0; p < 0.001) and larger reduction in pain now (−1.1; 95% CI: −1.9 to −0.3; p = 0.009) compared with the control group. No association was found between changes in pain now and weight loss. Both groups experienced improvements in several QoL dimensions.

Conclusions

Diet-induced weight loss in women with lipedema can improve QoL. An energy-restricted LCD seems to be superior to a standard control diet in reducing pain.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

低碳水化合物饮食对女性脂肪性水肿患者疼痛和生活质量的影响：随机对照试验

目的本研究的主要目的是评估低碳水化合物饮食（LCD）与对照饮食相比对女性脂肪性水肿患者疼痛的影响。次要目标是比较两种饮食对生活质量（QoL）的影响，并研究疼痛变化与体重、身体成分和酮病变化之间的潜在关联。方法将患有脂肪性水肿和肥胖症的成年女性患者随机分配到 LCD 或对照饮食（能量处方：1200 千卡/天）中，为期 8 周。结果共纳入了 70 名女性患者（平均年龄 [SD] 47 [11] 岁；体重指数 37 [5] kg/m2）。与对照组相比，LCD 组体重减轻幅度更大（-2.8 千克；95% CI：-4.1 至-1.0；p < 0.001），疼痛减轻幅度更大（-1.1；95% CI：-1.9 至-0.3；p = 0.009）。目前疼痛的变化与体重减轻之间没有关联。结论患有脂肪性水肿的女性通过饮食减肥可以改善 QoL。在减轻疼痛方面，限制能量的 LCD 似乎优于标准控制饮食。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.