The connection of motor improvement after deep brain stimulation in Parkinson’s disease and microstructural integrity of the substantia nigra and subthalamic nucleus

IF 3.4 2区医学 Q2 NEUROIMAGING Neuroimage-Clinical Pub Date : 2024-01-01 DOI:10.1016/j.nicl.2024.103607

Marco G. Hermann , Nils Schröter , Alexander Rau , Marco Reisert , Nadja Jarc , Michel Rijntjes , Jonas A. Hosp , Peter C. Reinacher , Wolfgang H. Jost , Horst Urbach , Cornelius Weiller , Volker A. Coenen , Bastian E.A. Sajonz

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Abstract

Background

Nigrostriatal microstructural integrity has been suggested as a biomarker for levodopa response in Parkinson’s disease (PD), which is a strong predictor for motor response to deep brain stimulation (DBS) of the subthalamic nucleus (STN). This study aimed to explore the impact of microstructural integrity of the substantia nigra (SN), STN, and putamen on motor response to STN-DBS using diffusion microstructure imaging.

Methods

Data was collected from 23 PD patients (mean age 63 ± 7, 6 females) who underwent STN-DBS, had preoperative 3 T diffusion magnetic resonance imaging including multishell diffusion-weighted MRI with b-values of 1000 and 2000 s/mm² and records of motor improvement available.

Results

The association between a poorer DBS-response and increased free interstitial fluid showed notable effect sizes (rho > |0.4|) in SN and STN, but not in putamen. However, this did not reach significance after Bonferroni correction and controlling for sex and age.

Conclusion

Microstructural integrity of SN and STN are potential biomarkers for the prediction of therapy efficacy following STN-DBS, but further studies are required to confirm these associations.

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帕金森病患者接受脑深部刺激后运动能力的改善与黑质和丘脑下核微结构完整性的关系

背景有研究认为，黑质微结构完整性是帕金森病（PD）患者左旋多巴反应的生物标志物，而左旋多巴反应是眼下核（STN）深部脑刺激（DBS）运动反应的有力预测指标。本研究旨在利用弥散微结构成像技术探讨黑质（SN）、STN 和普鲁曼的微结构完整性对 STN-DBS 运动反应的影响。方法收集了23名接受STN-DBS治疗的帕金森病患者（平均年龄63±7岁，女性6名）的数据，这些患者术前接受了3 T弥散磁共振成像，包括b值为1000和2000 s/mm2的多壳弥散加权磁共振成像，并有运动改善记录。结果在黑质和STN中，较差的DBS反应与游离间质增加之间的关联显示出显著的效应大小（rho >|0.4|），但在普鲁士门中没有。结论SN和STN的微结构完整性是预测STN-DBS治疗效果的潜在生物标志物，但还需要进一步的研究来证实这些关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroimage-Clinical NEUROIMAGING-

CiteScore

7.50

自引率

4.80%

发文量

368

审稿时长

52 days

期刊介绍： NeuroImage: Clinical, a journal of diseases, disorders and syndromes involving the Nervous System, provides a vehicle for communicating important advances in the study of abnormal structure-function relationships of the human nervous system based on imaging. The focus of NeuroImage: Clinical is on defining changes to the brain associated with primary neurologic and psychiatric diseases and disorders of the nervous system as well as behavioral syndromes and developmental conditions. The main criterion for judging papers is the extent of scientific advancement in the understanding of the pathophysiologic mechanisms of diseases and disorders, in identification of functional models that link clinical signs and symptoms with brain function and in the creation of image based tools applicable to a broad range of clinical needs including diagnosis, monitoring and tracking of illness, predicting therapeutic response and development of new treatments. Papers dealing with structure and function in animal models will also be considered if they reveal mechanisms that can be readily translated to human conditions.