The role of microbiota in gastric cancer: A comprehensive review

IF 4.3 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Helicobacter Pub Date : 2024-04-20 DOI:10.1111/hel.13071

Changzhen Lei, Yitian Xu, Shaopeng Zhang, Chen Huang, Jing Qin

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Abstract

Background

Gastric cancer (GC) continues to pose a significant global threat in terms of cancer-related fatalities. Despite notable advancements in medical research and therapies, further investigation is warranted to elucidate its underlying etiology and risk factors. Recent times have witnessed an escalated emphasis on comprehending the role of the microbiota in cancer development.

Methods

This review briefly delves into recent developments in microbiome-related research pertaining to gastric cancer.

Results

According to studies, the microbiota can influence GC growth by inciting inflammation, disrupting immunological processes, and generating harmful microbial metabolites. Furthermore, there is ongoing research into how the microbiome can impact a patient's response to chemotherapy and immunotherapy.

Conclusion

The utilization of the microbiome for detecting, preventing, and managing stomach cancer remains an active area of exploration.

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微生物群在胃癌中的作用：全面回顾

背景胃癌（GC）仍然是全球癌症相关死亡的重大威胁。尽管医学研究和疗法取得了显著进展，但仍需进一步调查以阐明其潜在病因和风险因素。近来，人们越来越重视了解微生物群在癌症发展中的作用。方法本综述简要探讨与胃癌有关的微生物群相关研究的最新进展。结果根据研究，微生物群可通过诱发炎症、干扰免疫过程和产生有害的微生物代谢产物来影响胃癌的生长。此外，有关微生物群如何影响患者对化疗和免疫疗法的反应的研究也在进行中。结论利用微生物组检测、预防和管理胃癌仍是一个积极探索的领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Helicobacter 医学-微生物学

CiteScore

8.40

自引率

9.10%

发文量

审稿时长

2 months

期刊介绍： Helicobacter is edited by Professor David Y Graham. The editorial and peer review process is an independent process. Whenever there is a conflict of interest, the editor and editorial board will declare their interests and affiliations. Helicobacter recognises the critical role that has been established for Helicobacter pylori in peptic ulcer, gastric adenocarcinoma, and primary gastric lymphoma. As new helicobacter species are now regularly being discovered, Helicobacter covers the entire range of helicobacter research, increasing communication among the fields of gastroenterology; microbiology; vaccine development; laboratory animal science.