High-dose pulsed hyaluronidase for managing nasal skin necrosis following hyaluronic acid treatment in nasolabial folds: A case report

Q1 Medicine Journal of oral biology and craniofacial research Pub Date : 2024-04-22 DOI:10.1016/j.jobcr.2024.04.006

Marcelo Germani , Panmella Alegria , Gabriela Giro , Victor R.M. Munoz-Lora

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Abstract

The growing popularity of soft tissue filler injections has brought attention to the associated risks, particularly vascular complications, and their treatments. This case report focuses on a 34-year-old female who developed nasal skin necrosis following hyaluronic acid (HA) filler injection for nasolabial fold (NLF) enhancement. Despite the careful procedure, complications emerged rapidly, emphasizing the critical importance of prompt diagnosis and intervention. A total of 10,000 turbidity reducing units (TRU) of hyaluronidase (HSE) were administered in a high-dose pulsed manner, alongside hyperbaric oxygen therapy. The patient experienced a gradual but significant improvement over 60 days. This case underscores the need for constant vigilance in aesthetic medicine and the potential consequences of even minute HA amounts, exceeding zero, in causing severe vascular events.

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高剂量脉冲透明质酸酶用于处理鼻唇沟透明质酸治疗后的鼻部皮肤坏死：病例报告

随着软组织填充注射的日益普及，相关风险（尤其是血管并发症）及其治疗方法也备受关注。本病例报告主要讲述了一名 34 岁的女性在注射透明质酸（HA）填充物以改善鼻唇沟（NLF）后出现鼻部皮肤坏死的情况。尽管手术过程非常谨慎，但并发症还是迅速出现，这就强调了及时诊断和干预的重要性。在进行高压氧治疗的同时，以大剂量脉冲方式注射了总计 10,000 个透明质酸酶降浊单位（TRU）。在 60 天的时间里，患者的病情逐渐得到明显改善。这个病例突出表明，美容医学需要时刻保持警惕，即使微量的 HA 超过零，也有可能导致严重的血管事件。

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来源期刊

Journal of oral biology and craniofacial research Medicine-Otorhinolaryngology

CiteScore

4.90

自引率

0.00%

发文量

133

审稿时长

167 days

期刊介绍： Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.