EFFECT OF MORINGA (Moringa oleifera) LEAF FLOUR ETHANOL EXTRACT ON REDUCTION OF BLOOD GLUCOSE IN MALE WISTAR STRAIN RATS INDUCED BY ALLOXAN

Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Pub Date : 2024-04-20 DOI:10.32539/jkk.v11i2.416

Ditya Ananda Safira, Susianti, Dyah Wulan Sumekar, Rengganis Wardani, J. Suwandi, Ditya Ananda, Safira, Kata Kunci, Tepung Daun, Kelor Moringa

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Abstract

This study is to determine the effect of giving ethanol extract of moringa leaf flour (Moringa oleifera) on reducing blood glucose levels of alloxan-induced Wistar Rattus norvegicus male rats. Using a true experimental design with a randomized pre and post control group approach. The sample used consisted of 35 male Wistar white rats. Data collection using simple random sampling technique. Paired t test gives the results of p<0.05 in all treatment groups, meaning that there are differences in fasting blood glucose levels of hyperglycemic rats before and after treatment. One way ANOVA test gave the result of p<0.001, meaning that all treatment groups showed a significant difference in the mean difference in fasting blood glucose levels before and after treatment. LSD post hoc test results showed a significant mean difference in fasting blood glucose levels before and after treatment of P1 and P2 with all treatment groups (p<0.001). Probit analysis test obtained ED50=1447,84 mg/kgBB.

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辣木（Moringa oleifera）叶面乙醇提取物对阿洛糖诱导的雄性猕猴血糖降低的影响

本研究旨在确定给予辣木叶粉（Moringa oleifera）乙醇提取物对降低阿洛糖诱导的 Wistar Rattus norvegicus 雄性大鼠血糖水平的影响。该研究采用了真正的实验设计和随机的前后对照组方法。使用的样本包括 35 只雄性 Wistar 白鼠。采用简单随机抽样技术收集数据。所有治疗组的配对 t 检验结果均为 p<0.05，这意味着高血糖大鼠在治疗前后的空腹血糖水平存在差异。单因素方差分析的结果为 p<0.001，这意味着所有治疗组治疗前后的空腹血糖平均值差异显著。LSD 事后检验结果显示，P1 和 P2 治疗前后的空腹血糖平均值与所有治疗组相比均有显著差异（P<0.001）。Probit 分析测试得出 ED50=1447,84 mg/kgBB。

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Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya

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