Muhammad Raihan, Afif Kurniawan, Nur Riviati, B. Prananjaya, Muhammad Reagan, Syarifah Aini, Kata Kunci, 158 │ Muhammad, Raihan Afif, Kurniawan Et, Al
Sarcopenia in Elderly Patients: What are the Contributing Risk Factors?. Sarcopenia is the gradual loss of muscle mass associated with aging. The process by which sarcopenia occurs is not fully understood. Many factors are at risk of causing sarcopenia, such as age, gender, and physical activity. Early detection with the SARC-F questionnaire is needed to prevent sarcopenia. This study is a descriptive observational study with a cross-sectional approach with total sampling to see the description of sarcopenia and risk factors in elderly patients at the Geriatric Polyclinic of Dr. Mohammad Hoesin Hospital Palembang. Primary data were collected through interviews using a questionnaire, and then analyzed univariately. A total of 48.4% of the elderly at the Geriatric Polyclinic of Dr. Mohammad Hoesin Hospital Palembang had sarcopenia findings. Patients in the sarcopenia group were mostly aged 70-79 years (41.9%), female (64.5%), married (58.1%), history of primary education (32.3%), had worked (58.1%), had mild comorbidities (58.1%), sedentary physical activity (74.2%), and at risk of malnutrition (54.8%).
老年患者的 "肌肉疏松症"：诱发风险因素有哪些？肌肉疏松症是指随着年龄的增长，肌肉质量逐渐减少。肌肉疏松症的发生过程尚不完全清楚。许多因素都有可能导致肌肉疏松症，如年龄、性别和运动量。我们需要通过 SARC-F 问卷进行早期检测，以预防肌肉疏松症的发生。本研究是一项描述性观察研究，采用横断面方法进行总体抽样，以了解巴伦邦 Mohammad Hoesin 医生医院老年综合门诊中老年患者的肌肉疏松症描述和风险因素。原始数据是通过问卷调查收集的，然后进行单变量分析。在巴伦邦 Mohammad Hoesin 医生医院的老年病综合门诊中，共有 48.4% 的老人患有肌肉疏松症。肌肉疏松症患者的年龄多在 70-79 岁之间（41.9%），女性（64.5%），已婚（58.1%），受过初等教育（32.3%），工作过（58.1%），有轻微的并发症（58.1%），久坐不动（74.2%），有营养不良的风险（54.8%）。
{"title":"SARCOPENIA IN ELDERLY PATIENTS: WHAT ARE THE CONTRIBUTING RISK FACTORS?","authors":"Muhammad Raihan, Afif Kurniawan, Nur Riviati, B. Prananjaya, Muhammad Reagan, Syarifah Aini, Kata Kunci, 158 │ Muhammad, Raihan Afif, Kurniawan Et, Al","doi":"10.32539/jkk.v11i2.389","DOIUrl":"https://doi.org/10.32539/jkk.v11i2.389","url":null,"abstract":"Sarcopenia in Elderly Patients: What are the Contributing Risk Factors?. Sarcopenia is the gradual loss of muscle mass associated with aging. The process by which sarcopenia occurs is not fully understood. Many factors are at risk of causing sarcopenia, such as age, gender, and physical activity. Early detection with the SARC-F questionnaire is needed to prevent sarcopenia. This study is a descriptive observational study with a cross-sectional approach with total sampling to see the description of sarcopenia and risk factors in elderly patients at the Geriatric Polyclinic of Dr. Mohammad Hoesin Hospital Palembang. Primary data were collected through interviews using a questionnaire, and then analyzed univariately. A total of 48.4% of the elderly at the Geriatric Polyclinic of Dr. Mohammad Hoesin Hospital Palembang had sarcopenia findings. Patients in the sarcopenia group were mostly aged 70-79 years (41.9%), female (64.5%), married (58.1%), history of primary education (32.3%), had worked (58.1%), had mild comorbidities (58.1%), sedentary physical activity (74.2%), and at risk of malnutrition (54.8%).","PeriodicalId":516636,"journal":{"name":"Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140680524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noveline Sagita, Putri Thalia Handoko, Ardo Sanjaya, J. Gunadi, Neurosistiserkosis Kejang, Kemampuan Kognitif
Neurocysticercosis is one of the most encountered infectious diseases caused by parasites. This condition is caused by an infection of the larvae (cysticercus) of the tapeworm Taenia Solium in the central nervous system. One of the many clinical manifestations of this condition is recurrent seizures that can eventually lead to damage to brain tissue and its functions. This literature review aims to discuss the effect of seizures on the cognitive function of patients diagnosed with neurocysticercosis. The method used in this study is a systematic review with search engines (PubMed and the Cochrane Library) using the keywords “neurocysticercosis” and “seizure” and “cognitive”. Inclusion criteria for this literature review include articles and journals published in the last 10 years with full-text access. We found 6 articles comparing the cognitive abilities of neurocysticercosis-diagnosed patients with healthy control. This literature review concluded that neurocysticercosis patients tend to have lower cognitive function in certain aspects compared to healthy controls.
{"title":"THE IMPACT OF SEIZURES ON COGNITIVE ABILITIES OF PATIENTS DIAGNOSED WITH NEUROCYSTICERCOSIS: A SYSTEMATIC REVIEW","authors":"Noveline Sagita, Putri Thalia Handoko, Ardo Sanjaya, J. Gunadi, Neurosistiserkosis Kejang, Kemampuan Kognitif","doi":"10.32539/jkk.v11i2.409","DOIUrl":"https://doi.org/10.32539/jkk.v11i2.409","url":null,"abstract":"Neurocysticercosis is one of the most encountered infectious diseases caused by parasites. This condition is caused by an infection of the larvae (cysticercus) of the tapeworm Taenia Solium in the central nervous system. One of the many clinical manifestations of this condition is recurrent seizures that can eventually lead to damage to brain tissue and its functions. This literature review aims to discuss the effect of seizures on the cognitive function of patients diagnosed with neurocysticercosis. The method used in this study is a systematic review with search engines (PubMed and the Cochrane Library) using the keywords “neurocysticercosis” and “seizure” and “cognitive”. Inclusion criteria for this literature review include articles and journals published in the last 10 years with full-text access. We found 6 articles comparing the cognitive abilities of neurocysticercosis-diagnosed patients with healthy control. This literature review concluded that neurocysticercosis patients tend to have lower cognitive function in certain aspects compared to healthy controls.","PeriodicalId":516636,"journal":{"name":"Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140679834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This Study aims to determine whether there is a relationship between the habit of washing hands and STH infection in students of State Elementary School 106856 Tanjung Beringin, Serdang Bedagai, North Sumatra. This type of research is analytic observational. The research design used was a cross sectional study. The research will be conducted at SD Negeri 106856 Tanjung Beringin, Serdang Bedagai, North Sumatra. Examination of STH eggs will be carried out in the Parasitology laboratory of FK UMSU by means of the Kato-Katz examination. Sampling in this study used the total sampling method, where all students in grades I-VI became the research sample. Data analysis used the chi square test. The incidence of STH infection in students of SD Negeri 106856 was 29.4%. The results of the chi-square test between hand washing habits and STH infection were P-Value <0.05 (0.000 <0.05). There is a relationship between the habit of washing hands and STH infection in class I-VI students of Elementary School 106856 Tanjung Beringin, Serdang Bedagai, North Sumatra in 2022.
本研究旨在确定北苏门答腊Serdang Bedagai市106856 Tanjung Beringin国立小学学生的洗手习惯与感染性传播疾病之间是否存在关系。该研究属于分析观察型研究。采用的研究设计是横断面研究。研究将在北苏门答腊 Serdang Bedagai 的 Tanjung Beringin 106856 SD Negeri 进行。将在 FK UMSU 的寄生虫学实验室通过 Kato-Katz 检查法对 STH 虫卵进行检查。本研究采用总体抽样法，将一至六年级的所有学生作为研究样本。数据分析采用卡方检验。在106856号学生宿舍的学生中，性传播疾病感染率为29.4%。洗手习惯与 STH 感染之间的卡方检验结果为 P 值<0.05（0.000<0.05）。2022 年，北苏门答腊 Serdang Bedagai 的 Tanjung Beringin 106856 小学一至六年级学生的洗手习惯与 STH 感染之间存在关系。
{"title":"THE RELATIONSHIP BETWEEN HAND WASHING HABITS AND SOIL TRANSMITTED HELMINTH INFECTIONS IN STUDENTS AT PUBLIC ELEMENTARY SCHOOL 106856 TANJUNG BERINGIN","authors":"Diah Wulan Safitri, Nelli Murlina","doi":"10.32539/jkk.v11i2.414","DOIUrl":"https://doi.org/10.32539/jkk.v11i2.414","url":null,"abstract":"This Study aims to determine whether there is a relationship between the habit of washing hands and STH infection in students of State Elementary School 106856 Tanjung Beringin, Serdang Bedagai, North Sumatra. This type of research is analytic observational. The research design used was a cross sectional study. The research will be conducted at SD Negeri 106856 Tanjung Beringin, Serdang Bedagai, North Sumatra. Examination of STH eggs will be carried out in the Parasitology laboratory of FK UMSU by means of the Kato-Katz examination. Sampling in this study used the total sampling method, where all students in grades I-VI became the research sample. Data analysis used the chi square test. The incidence of STH infection in students of SD Negeri 106856 was 29.4%. The results of the chi-square test between hand washing habits and STH infection were P-Value <0.05 (0.000 <0.05). There is a relationship between the habit of washing hands and STH infection in class I-VI students of Elementary School 106856 Tanjung Beringin, Serdang Bedagai, North Sumatra in 2022.","PeriodicalId":516636,"journal":{"name":"Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140679727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rona Hawa Kamilah, Salni, Z. Maritska, Fatmawati, Rona Hawa, Kamilah Biomedical Science, Study Program, IL-1β Jalur, Inflamasi Hiperurisemia
Inflammatory conditions in hyperuricemia are caused by monosodium urate crystals that induce the release of IL-1β, marking a crucial milestone in the pathogenesis of hyperuricemia. Several studies have linked the relationship between serum uric acid levels and the release of IL-1β. IL-1β plays a key role in the pathogenesis of gout. The IL-1β signaling is currently considered an initiating event that triggers uric acid inflammation and promotes the recruitment of a large number of neutrophils to the inflammatory site. Neutrophil activation caused by crystals results in the inhibition of apoptosis, degranulation, the release of reactive oxygen species (ROS), TNF-α, IL-1β, and PGE2, as well as the formation of extracellular neutrophil tissue, further reinforcing the inflammatory process. Recent research indicates that hyperuricemia patients have significantly higher levels of IL-1β. Other studies suggest that elevated IL-1β levels correlate with a more severe anatomical pathology in the joint tissues of rat ankles, including synovial hyperplasia, cartilage damage, and bone erosion.
{"title":"SPECIFIC ROLE OF IL-1Β IN URIC ACID-RELATED INFLAMMATION : A NARRATIVE REVIEW","authors":"Rona Hawa Kamilah, Salni, Z. Maritska, Fatmawati, Rona Hawa, Kamilah Biomedical Science, Study Program, IL-1β Jalur, Inflamasi Hiperurisemia","doi":"10.32539/jkk.v11i2.396","DOIUrl":"https://doi.org/10.32539/jkk.v11i2.396","url":null,"abstract":"Inflammatory conditions in hyperuricemia are caused by monosodium urate crystals that induce the release of IL-1β, marking a crucial milestone in the pathogenesis of hyperuricemia. Several studies have linked the relationship between serum uric acid levels and the release of IL-1β. IL-1β plays a key role in the pathogenesis of gout. The IL-1β signaling is currently considered an initiating event that triggers uric acid inflammation and promotes the recruitment of a large number of neutrophils to the inflammatory site. Neutrophil activation caused by crystals results in the inhibition of apoptosis, degranulation, the release of reactive oxygen species (ROS), TNF-α, IL-1β, and PGE2, as well as the formation of extracellular neutrophil tissue, further reinforcing the inflammatory process. Recent research indicates that hyperuricemia patients have significantly higher levels of IL-1β. Other studies suggest that elevated IL-1β levels correlate with a more severe anatomical pathology in the joint tissues of rat ankles, including synovial hyperplasia, cartilage damage, and bone erosion.","PeriodicalId":516636,"journal":{"name":"Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140681419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Malaria treatment depends on the clinical degree of the disease and can cause death if not treated appropriately. This study looks at factors associated with the clinical degree of malaria in elimination areas in Indonesia. The research design used a cross-sectional quantitative study of secondary data from the Malaria Surveillance Information System (Sismal) application in 2023 in all 9435 elimination districts in Indonesia. Analysis was conducted on each variable to see the frequency distribution and percentage of each variable. Data was processed with the SPSS program. Multivariate analysis showed that anemia (p=0.000; OR=11.748; CI 95% =7.833-17.620) and treatment status (p=0.000; OR=8.554; CI 95% =5.694-12.851) had p<0.05. It can be concluded that anemia and treatment status are significantly associated with the clinical degree of malaria. In elimination areas, because cases are rare, training is needed for health workers to provide appropriate and rapid diagnosis and treatment so that no infection or recurrence causes severe anemia and death. Many factors affect the clinical degree of malaria. However, the variables employed are constrained, necessitating further investigation into a comprehensive array of factors influencing the clinical severity of malaria.
{"title":"FACTORS RELATED TO THE CLINICAL DEGREE OF MALARIA IN ELIMINATION AREAS IN INDONESIA","authors":"Aneke Theresia, Helda, Malaria Derajat, Klinis Daerah, Eliminasi","doi":"10.32539/jkk.v11i2.424","DOIUrl":"https://doi.org/10.32539/jkk.v11i2.424","url":null,"abstract":"Malaria treatment depends on the clinical degree of the disease and can cause death if not treated appropriately. This study looks at factors associated with the clinical degree of malaria in elimination areas in Indonesia. The research design used a cross-sectional quantitative study of secondary data from the Malaria Surveillance Information System (Sismal) application in 2023 in all 9435 elimination districts in Indonesia. Analysis was conducted on each variable to see the frequency distribution and percentage of each variable. Data was processed with the SPSS program. Multivariate analysis showed that anemia (p=0.000; OR=11.748; CI 95% =7.833-17.620) and treatment status (p=0.000; OR=8.554; CI 95% =5.694-12.851) had p<0.05. It can be concluded that anemia and treatment status are significantly associated with the clinical degree of malaria. In elimination areas, because cases are rare, training is needed for health workers to provide appropriate and rapid diagnosis and treatment so that no infection or recurrence causes severe anemia and death. Many factors affect the clinical degree of malaria. However, the variables employed are constrained, necessitating further investigation into a comprehensive array of factors influencing the clinical severity of malaria.","PeriodicalId":516636,"journal":{"name":"Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140679953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noor Amaliah, Noor Hadijah, Zainal Aripin, Perencanaan Pemulangan, Kinerja Perawat Dokumentasi
Nurse performance is an activity in implementing authority, duties and responsibilities in order to achieve the main tasks of the profession and organization. Discharge planning is a stage that has the goal of preparing the patient during the post-treatment transition period so that he can return home. Purpose of this study in general was to determine the corre. lation between nurse performance and successful documentation in the implementation of discharge planning at inpatient care at Hospital, Banjarmasin. Method this research is quantitative by using infants and post-partum care, totaling 6,5 executive nurse. in taking the simple Random Sampling Technique. Result. Thus it can be concluded that there is a correlation between the performance variables of nurses and the implementation of discharge planning in the inpatient care of Hospital, Banjarmasin. Health services are expected to always improve the performance of good nurses for health services, especially nurses in implementing discharge planning for patients, nurse performance is very important in completing nursing tasks such as implementing discharge planning in hospitalization. In order to create good quality for the quality of health services in hospitals.
{"title":"NURSE PERFORMANCE INFLUENCES DOCUMENTATION SUCCESS IN IMPLEMENTING DISCHARGE PLANNING IN INPATIENT CARE AT THE HOSPITAL IN BANJARMASIN","authors":"Noor Amaliah, Noor Hadijah, Zainal Aripin, Perencanaan Pemulangan, Kinerja Perawat Dokumentasi","doi":"10.32539/jkk.v11i2.370","DOIUrl":"https://doi.org/10.32539/jkk.v11i2.370","url":null,"abstract":"Nurse performance is an activity in implementing authority, duties and responsibilities in order to achieve the main tasks of the profession and organization. Discharge planning is a stage that has the goal of preparing the patient during the post-treatment transition period so that he can return home. Purpose of this study in general was to determine the corre. lation between nurse performance and successful documentation in the implementation of discharge planning at inpatient care at Hospital, Banjarmasin. Method this research is quantitative by using infants and post-partum care, totaling 6,5 executive nurse. in taking the simple Random Sampling Technique. Result. Thus it can be concluded that there is a correlation between the performance variables of nurses and the implementation of discharge planning in the inpatient care of Hospital, Banjarmasin. Health services are expected to always improve the performance of good nurses for health services, especially nurses in implementing discharge planning for patients, nurse performance is very important in completing nursing tasks such as implementing discharge planning in hospitalization. In order to create good quality for the quality of health services in hospitals.","PeriodicalId":516636,"journal":{"name":"Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140680706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future research will continue to be carried out in terms of looking for molecular markers involved in the early processes of carcinogenesis, metastasis and therapeutic targets in prostate cancer patients. MicroRNAs (miRNAs) are small noncoding RNAs that contribute to prostate cancer progression by controlling genes involved in the androgen receptor (AR) signaling pathway, ectopic expression of proteins involved in the cell cycle and apoptosis, epithelial-mesenchymal transition (EMT) and metastasis of cancer stem cells (CSCs). This study was an exploratory study, the aim was to assess miRNA expression in low histopathological grade prostate cancer compared with high histopathological grade prostate cancer. The novelty of this research is to assess the 25 most increased (up-regulated) and 25 lowest (down-regulated) miRNAs from 800 types of miRNA. Next, we will analyze the mechanisms and confirm the carcinogenesis of prostate cancer. The research results can be used for further research data, especially for targeted therapy in prostate cancer patients.
{"title":"MicroRNA (miRNA) PROFILING IN PROSTATE CANCER CARCINOGENESIS: EXPLORATORY RESEARCH","authors":"Maria Ulfa, Krisna Murti","doi":"10.32539/jkk.v11i2.377","DOIUrl":"https://doi.org/10.32539/jkk.v11i2.377","url":null,"abstract":"Future research will continue to be carried out in terms of looking for molecular markers involved in the early processes of carcinogenesis, metastasis and therapeutic targets in prostate cancer patients. MicroRNAs (miRNAs) are small noncoding RNAs that contribute to prostate cancer progression by controlling genes involved in the androgen receptor (AR) signaling pathway, ectopic expression of proteins involved in the cell cycle and apoptosis, epithelial-mesenchymal transition (EMT) and metastasis of cancer stem cells (CSCs). This study was an exploratory study, the aim was to assess miRNA expression in low histopathological grade prostate cancer compared with high histopathological grade prostate cancer. The novelty of this research is to assess the 25 most increased (up-regulated) and 25 lowest (down-regulated) miRNAs from 800 types of miRNA. Next, we will analyze the mechanisms and confirm the carcinogenesis of prostate cancer. The research results can be used for further research data, especially for targeted therapy in prostate cancer patients.","PeriodicalId":516636,"journal":{"name":"Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140681824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The isolation and identification of secondary wound infection bacteria in diabetic patients in Jambi City are crucial for developing effective treatment strategies. The diversity of infecting bacteria underscores the importance of discerning the most prevalent types. This research aims to identify bacteria causing secondary wound infections in diabetic patients. Researchers obtained samples for this descriptive cross-sectional study by swabbing the incisions of diabetic patients at RSUD H. Abdul Manap in Jambi City between August and October 2023. Gram staining, culturing, and enzymatic tests were performed on the samples. Out of 21 samples, the age group most affected was 45-59 years (61.9%), predominantly male (81%), engaged in high-risk occupations (42.9%), with lower extremity wounds (90.5%), and primary wounds diagnosed as vulnus scissum and vulnus abrasio (33.3%). In contrast, DM ulcers constituted 66.7% of secondary wound infections in diabetic patients. Bacterial identification revealed Staphylococcus aureus as the predominant species (42.9%) responsible for secondary wound infections in diabetic patients. This study underscores the dominance of Staphylococcus aureus in secondary wound infections among diabetic patients.
在占碑市的糖尿病患者中分离和鉴定继发性伤口感染细菌对于制定有效的治疗策略至关重要。感染细菌的多样性凸显了分辨最常见类型的重要性。本研究旨在确定导致糖尿病患者继发性伤口感染的细菌。研究人员于 2023 年 8 月至 10 月间在占碑市的 H. Abdul Manap RSUD 对糖尿病患者的切口进行了拭抹，从而获得了样本。对样本进行了革兰氏染色、培养和酶学检测。在 21 份样本中，受影响最大的年龄组为 45-59 岁（61.9%），主要为男性（81%），从事高危职业（42.9%），下肢伤口（90.5%），原发伤口诊断为溃疡（33.3%）。相比之下，DM溃疡占糖尿病患者继发性伤口感染的66.7%。细菌鉴定显示，金黄色葡萄球菌是糖尿病患者继发性伤口感染的主要菌种（42.9%）。这项研究强调了金黄色葡萄球菌在糖尿病患者继发性伤口感染中的主导地位。
{"title":"ISOLATION AND IDENTIFICATION OF BACTERIA CAUSING SECONDARY WOUND INFECTIONS IN DIABETES MELLITUS PATIENTS IN JAMBI CITY","authors":"Qatrinnada Maulidya Akmal, Humaryanto, Lipinwati, Rita Halim","doi":"10.32539/jkk.v11i2.395","DOIUrl":"https://doi.org/10.32539/jkk.v11i2.395","url":null,"abstract":"The isolation and identification of secondary wound infection bacteria in diabetic patients in Jambi City are crucial for developing effective treatment strategies. The diversity of infecting bacteria underscores the importance of discerning the most prevalent types. This research aims to identify bacteria causing secondary wound infections in diabetic patients. Researchers obtained samples for this descriptive cross-sectional study by swabbing the incisions of diabetic patients at RSUD H. Abdul Manap in Jambi City between August and October 2023. Gram staining, culturing, and enzymatic tests were performed on the samples. Out of 21 samples, the age group most affected was 45-59 years (61.9%), predominantly male (81%), engaged in high-risk occupations (42.9%), with lower extremity wounds (90.5%), and primary wounds diagnosed as vulnus scissum and vulnus abrasio (33.3%). In contrast, DM ulcers constituted 66.7% of secondary wound infections in diabetic patients. Bacterial identification revealed Staphylococcus aureus as the predominant species (42.9%) responsible for secondary wound infections in diabetic patients. This study underscores the dominance of Staphylococcus aureus in secondary wound infections among diabetic patients.","PeriodicalId":516636,"journal":{"name":"Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140682248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diabetic foot ulcer is a chronic and frequent complication in diabetic patients. Foot ulcers occur in 15-25% of people with diabetes, and most of them require amputation. Conventional treatments for DFU have not been effective enough to reduce the amputation rates. Thus, an effective method to accelerate the healing of diabetic foot ulcers is required. Recently, stem cells have emerged as a promising adjuvant therapy. One of the numerous types of stem cells used in chronic wound healing therapy is Mesenchymal Stem Cells (MSCs). MSCs may be associated with shorter wound healing time, rapid tissue regeneration, and reduced risk of lower limb amputation through all mechanisms. This article summarizes and critically reviews the published literature on the use of MSCs to enhance chronic wound healing in DFUs.
{"title":"MESENCHYMAL STEM CELLS (MSCS) AS A THERAPY FOR CHRONIC WOUND HEALING IN DIABETIC FOOT ULCERS: A REVIEW ARTICLE","authors":"Nedya Bellinawati, L. Legiran","doi":"10.32539/jkk.v11i2.262","DOIUrl":"https://doi.org/10.32539/jkk.v11i2.262","url":null,"abstract":"Diabetic foot ulcer is a chronic and frequent complication in diabetic patients. Foot ulcers occur in 15-25% of people with diabetes, and most of them require amputation. Conventional treatments for DFU have not been effective enough to reduce the amputation rates. Thus, an effective method to accelerate the healing of diabetic foot ulcers is required. Recently, stem cells have emerged as a promising adjuvant therapy. One of the numerous types of stem cells used in chronic wound healing therapy is Mesenchymal Stem Cells (MSCs). MSCs may be associated with shorter wound healing time, rapid tissue regeneration, and reduced risk of lower limb amputation through all mechanisms. This article summarizes and critically reviews the published literature on the use of MSCs to enhance chronic wound healing in DFUs.","PeriodicalId":516636,"journal":{"name":"Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140679509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ilham Ardi Wibowo, Dina Helianti, Ulfa Elfiah, Rosita Dewi, Ayu Munawaroh Aziz, Kulit Bawang, Merah Diazinon Kadar, Mda Plasma
Diazinon is an organophosphate pesticide commonly used by farmers. The use of diazinon can leave residues on agricultural products. Consumption of these products in the long term will cause health problems through oxidative stress mechanisms. Onion skin (Allium et al.) has a high content of flavonoids, which can neutralize oxidative stress. This study aims to determine the effectiveness of onion peel ethanol extract (OPEE) in reducing the plasma MDA level in diazinon-induced Wistar rats. Method This study is true experimental with a posttest-only control group design in vivo, using 28 samples divided based on a simple random sampling technique into four groups, i.e. the control group (K0), diazinon group (K1), OPEE groups P1 (300 mg/kgBW), P2 (600 mg/kgBW), P3 (900 mg/kgBW), P4 (1200 mg/kgBW), and P5 (2400 mg/kg BW). The examination of plasma MDA levels was carried out using the TBARS method. OPEE at doses of 300 mg/kgBW/day, 600 mg/kgBW/day, 900 mg/kgBW/day, 1200 mg/kgBW/day, and 2400 mg/kgBW/day significantly reduced the plasma MDA levels in diazinon-induced Wistar rats (p<0.05). The plasma MDA level in the OPEE group at a dose of 2400mg/kgBW/day was not significantly different from the control group, indicating that OPEE at a dose of 2400mg/kgBW/day could neutralize the increase of plasma MDA level in diazinon-induced Wistar rat. OPEE is effective in reducing the plasma MDA level in diazinon-induced Wistar rats.
{"title":"ETHANOL EXTRACT OF ONION PEEL EFFECTIVELY REDUCES MALONDIALDEHYDE (MDA) LEVELS OF WISTAR RAT PLASMA INDUCED BY DIAZINON","authors":"Ilham Ardi Wibowo, Dina Helianti, Ulfa Elfiah, Rosita Dewi, Ayu Munawaroh Aziz, Kulit Bawang, Merah Diazinon Kadar, Mda Plasma","doi":"10.32539/jkk.v11i2.422","DOIUrl":"https://doi.org/10.32539/jkk.v11i2.422","url":null,"abstract":"Diazinon is an organophosphate pesticide commonly used by farmers. The use of diazinon can leave residues on agricultural products. Consumption of these products in the long term will cause health problems through oxidative stress mechanisms. Onion skin (Allium et al.) has a high content of flavonoids, which can neutralize oxidative stress. This study aims to determine the effectiveness of onion peel ethanol extract (OPEE) in reducing the plasma MDA level in diazinon-induced Wistar rats. Method This study is true experimental with a posttest-only control group design in vivo, using 28 samples divided based on a simple random sampling technique into four groups, i.e. the control group (K0), diazinon group (K1), OPEE groups P1 (300 mg/kgBW), P2 (600 mg/kgBW), P3 (900 mg/kgBW), P4 (1200 mg/kgBW), and P5 (2400 mg/kg BW). The examination of plasma MDA levels was carried out using the TBARS method. OPEE at doses of 300 mg/kgBW/day, 600 mg/kgBW/day, 900 mg/kgBW/day, 1200 mg/kgBW/day, and 2400 mg/kgBW/day significantly reduced the plasma MDA levels in diazinon-induced Wistar rats (p<0.05). The plasma MDA level in the OPEE group at a dose of 2400mg/kgBW/day was not significantly different from the control group, indicating that OPEE at a dose of 2400mg/kgBW/day could neutralize the increase of plasma MDA level in diazinon-induced Wistar rat. OPEE is effective in reducing the plasma MDA level in diazinon-induced Wistar rats. \u0000 ","PeriodicalId":516636,"journal":{"name":"Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140679309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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