{"title":"[Research status of animal models of secretory otitis media].","authors":"Q. Wan, H. B. Shi","doi":"10.3760/cma.j.cn115330-20231008-00124","DOIUrl":null,"url":null,"abstract":"\n 分泌性中耳炎（secretory otitis media，SOM），亦称渗出性中耳炎（otitis media effusion，OME），是以传导性聋及鼓室积液为主要特征的中耳非化脓性炎性疾病。OME为临床常见疾病，在学龄前儿童中发病率尤高。OME病因复杂，在基础研究中难以获得与人类OME发病高度一致的动物模型，相关病理生理机制研究和治疗方法受限。本文归纳了OME造模动物的种类，并从咽鼓管功能障碍、感染及免疫反应这3个可能与OME相关的病因入手，阐述了手术致咽鼓管功能障碍、中耳鼓室注射诱导、基因变异3大类OME动物模型，对其优缺点及适用情况进行了讨论。.\n","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"17 10","pages":"405-410"},"PeriodicalIF":0.0000,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese journal of otorhinolaryngology head and neck surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/cma.j.cn115330-20231008-00124","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
分泌性中耳炎（secretory otitis media，SOM），亦称渗出性中耳炎（otitis media effusion，OME），是以传导性聋及鼓室积液为主要特征的中耳非化脓性炎性疾病。OME为临床常见疾病，在学龄前儿童中发病率尤高。OME病因复杂，在基础研究中难以获得与人类OME发病高度一致的动物模型，相关病理生理机制研究和治疗方法受限。本文归纳了OME造模动物的种类，并从咽鼓管功能障碍、感染及免疫反应这3个可能与OME相关的病因入手，阐述了手术致咽鼓管功能障碍、中耳鼓室注射诱导、基因变异3大类OME动物模型，对其优缺点及适用情况进行了讨论。.
分泌性中耳炎（secretory otitis media，SOM），亦称渗出性中耳炎（otitis media effusion，OME），是以传导性聋及鼓室积液为主要特征的中耳非化脓性炎性疾病。OME为临床常见疾病，在学龄前儿童中发病率尤高。OME病因复杂，在基础研究中难以获得与人类OME发病高度一致的动物模型，相关病理生理机制研究和治疗方法受限。本文归纳了OME造模动物的种类，并从咽鼓管功能障碍、感染及免疫反应这3个可能与OME相关的病因入手，阐述了手术致咽鼓管功能障碍、中耳鼓室注射诱导、基因变异3大类OME动物模型，对其优缺点及适用情况进行了讨论。.
期刊介绍：
Chinese journal of otorhinolaryngology head and neck surgery is a high-level medical science and technology journal sponsored and published directly by the Chinese Medical Association, reflecting the significant research progress in the field of otorhinolaryngology head and neck surgery in China, and striving to promote the domestic and international academic exchanges for the purpose of running the journal.
Over the years, the journal has been ranked first in the total citation frequency list of national scientific and technical journals published by the Documentation and Intelligence Center of the Chinese Academy of Sciences and the China Science Citation Database, and has always ranked first among the scientific and technical journals in the related fields.
Chinese journal of otorhinolaryngology head and neck surgery has been included in the authoritative databases PubMed, Chinese core journals, CSCD.
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