The role of the AP-1 adaptor complex in outgoing and incoming membrane traffic

M. S. Robinson, Robin Antrobus, Anneri Sanger, A. Davies, David C. Gershlick
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Abstract

Robinson et al. investigate AP-1 function using complementary approaches on cells coexpressing tagged AP-1 and cargo proteins. Their results support a model in which AP-1 is recruited onto post-Golgi carriers and early/recycling endosomes, where it retrieves selected proteins back to the TGN.
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AP-1 适配复合物在传出和传入膜交通中的作用
Robinson 等人在共表达标记 AP-1 和货物蛋白的细胞上使用互补方法研究了 AP-1 的功能。他们的研究结果支持这样一个模型:AP-1 被招募到后高尔基体载体和早期/循环内体上,并在那里将选定的蛋白质检索回 TGN。
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