EVALUATION OF GREENNESS PROFILES OF VARIOUS DEVELOPED METHODS FOR THE DETERMINATION OF COMMONLY USED NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) IN ENVIRONMENTAL WATERS

Ankara Universitesi Eczacilik Fakultesi Dergisi Pub Date : 2024-04-02 DOI:10.33483/jfpau.1425350

B. Sezgin, M. Soyseven

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Abstract

Objective: In our study, it was aimed to make a comparative analysis of the environmental impact profiles of two approaches including Gas Chromatography (GC) and Liquid Chromatography (LC) methods, which are frequently used techniques for the determination of non-steroidal anti-inflammatory drugs (NSAIDs) and their metabolites in environmental water samples. Material and Method: The evaluation of the methods' environmental impact was performed using National Environmental Methods Index Label (NEMI), Analytical Eco-scale, Analytical GREEnness Metric (AGREE), and Green Analytical Procedure Index (GAPI). Result and Discussion: The routine analysis of NSAIDs in environmental waters is carried out, resulting in a significant volume of chemical waste. In recent times, there has been a growing significance attributed to environmentally conscious analytical methodologies and the evaluation of methodologies through a green lens to confront this challenge. There is no statistically significant difference in terms of environmental impact profile was observed between the two methods compared.

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评价用于检测环境水体中常用非甾体抗炎药物（NSAIDs）的各种已开发方法的灰度特征

研究目的我们的研究旨在比较分析两种方法对环境的影响，包括气相色谱法（GC）和液相色谱法（LC），这两种方法是测定环境水样中非甾体抗炎药（NSAIDs）及其代谢物的常用技术：采用国家环境方法指数标签（NEMI）、分析生态尺度、分析优度（AGREE）和绿色分析程序指数（GAPI）对方法的环境影响进行评价：对环境水体中的非甾体抗炎药进行常规分析会产生大量化学废物。近来，人们越来越重视具有环保意识的分析方法，并通过绿色视角对方法进行评估，以应对这一挑战。经比较，两种方法在环境影响方面没有明显的统计学差异。

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Ankara Universitesi Eczacilik Fakultesi Dergisi

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