Mellissa officinalis Leaf Aqueous Extract Green-Formulated Nanoparticles as a new Chemotherapeutic Drug in the Field of Healthcare and Nursing: Determination of Anti-Cancer, Antioxidant, and Cytotoxicity Effects

Abstract

Nanotechnology is increasingly transforming healthcare and patient care. It also affects the distribution of drugs. To adapt to these changes in drug delivery, doctors need to educate and prepare themselves. To achieve the right treatment, doctors and examiners need to understand the metabolism and pharmacokinetics of nanomedicines. Also, researchers have confirmed the unique role of herbal nanoparticles in treating several cancers and their efficacy in healthcare and nursing. Herbal nanoparticles have demonstrated their efficacy across several Gram-positive and negative bacteria and various types of cancers. Traditional carcinoma treatment options such as radiotherapy and chemotherapy have the potential to enhance the patient’s well-being in certain instances, but they are consistently linked to notable adverse reactions. The investigation involved examining the efficacies of a tin nanoparticles green formulation created by Mellissa officinalis on human lung cancer cells. To assess the nanoparticles’ efficacy against lung cancer and their cytotoxicity against HUVEC cell line, the MTT examination was followed. The MTT results indicated that a concentration of 220, 151, 125, and 174 μg/ml of nanoparticles are the IC50. Furthermore, the carcinoma cells survival rate decreased with increasing concentrations of nanoparticles, with no viable cells observed at a 1000 μg/ml concentration after 72 hours. The highest cytotoxicity was observed at a 1000 μg/ml concentration. The study also revealed that the antioxidant activity peaked at 1000 μg/ml, exceeding 100%.