The effect of Citrus aurantium L. flower extract on the severity of primary dysmenorrhoea: a double-blind, randomised, controlled clinical trial

IF 2.2 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Journal of Herbal Medicine Pub Date : 2024-04-04 DOI:10.1016/j.hermed.2024.100878
Farkhondeh Aboualsoltani , Parvin Bastani , Laleh Khodaie , Seyyed Mohammad Bagher Fazljou , Hanieh Salehi-Pourmehr
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Abstract

Purpose

This study aimed to assess the effect of Citrus aurantium L. flower on the distance between two cycles, physical activity, days of bleeding, and intensity of dysmenorrhoea (primary objectives), and complications of interventions or adverse effects (secondary purpose).

Methods

This double-blind, randomised controlled clinical trial was conducted on 105 girls (15–20 years old) with primary dysmenorrhoea. In the intervention cycles, from the first to the third day, participants received 250 mg C. aurantium flower hydro-alcoholic extract capsule, Mefenamic acid (MA) capsule, or placebo three times a day based on the study groups.

Results

The results showed that the severity of dysmenorrhoea in the groups consuming C. aurantiumflower and MA was significantly lower than that before the intervention and compared to the placebo group (P< 0.001), which this reduction in the severity of pain in the C. aurantium flower group was also significantly higher than that of the MA group (P< 0.001) at the first and second days.

Conclusion

C. aurantium flower had higher efficacy and satisfaction rate and lower side effects in reducing the severity of primary dysmenorrhoea compared to MA.

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枳实花提取物对原发性痛经严重程度的影响:双盲、随机、对照临床试验
目的 本研究旨在评估枳壳花对两个周期之间的距离、体力活动、出血天数和痛经强度(主要目的)以及干预并发症或不良反应(次要目的)的影响。方法 本双盲随机对照临床试验的对象是105名患有原发性痛经的女孩(15-20岁)。在干预周期内,从第一天到第三天,参与者根据研究组每天三次服用 250 毫克枳壳花水醇提取物胶囊、甲氰咪胍(MA)胶囊或安慰剂。结果结果显示,服用枳壳花和甲氰咪胍组的痛经严重程度明显低于干预前和安慰剂组(P< 0.结论与 MA 相比,枳实花在降低原发性痛经严重程度方面具有更高的疗效和满意度,副作用更低。
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来源期刊
Journal of Herbal Medicine
Journal of Herbal Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
3.90
自引率
0.00%
发文量
94
期刊介绍: The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.
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