Exploring the role of OXTR gene methylation in attachment development: A longitudinal study

IF 1.8 4区心理学 Q3 DEVELOPMENTAL BIOLOGY Developmental psychobiology Pub Date : 2024-04-30 DOI:10.1002/dev.22496

Bien Cuyvers, Tsachi Ein-Dor, Melisse Houbrechts, Kathleen Freson, Luc Goossens, Wim Van Den Noortgate, Karla van Leeuwen, Patricia Bijttebier, Stephan Claes, Jonathan Turner, Viktoria Chubar, Marian J. Bakermans-Kranenburg, Guy Bosmans

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Abstract

The current study explored longitudinally whether oxytocin receptor gene methylation (OXTRm) changes moderated the association between parental sensitivity changes and children's attachment changes over three waves. Six hundred six Flemish children (10–12 years, 42.8%–44.8% boys) completed attachment measures and provided salivary OXTRm data on seven CpG sites. Their parents reported their sensitive parenting. Results suggest that OXTRm changes hardly link to attachment (in)security changes after the age of 10. Some support was found for interaction effects between parental sensitivity changes and OXTRm changes on attachment changes over time. Effects suggest that for children with increased OXTRm in the promotor region and decreased methylation in the inhibitor region over time, increased parental sensitivity was associated with increased secure attachment and decreased insecure attachment over time.

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探索 OXTR 基因甲基化在依恋发展中的作用：纵向研究

本研究纵向探讨了催产素受体基因甲基化（OXTRm）的变化是否会在三个波次中调节父母敏感性变化与儿童依恋变化之间的关联。600 名佛兰德儿童（10-12 岁，42.8%-44.8% 为男孩）完成了依恋测量，并提供了唾液中七个 CpG 位点的 OXTRm 数据。他们的父母则报告了他们敏感的养育方式。结果表明，OXTRm 的变化很难与 10 岁以后依恋（不）安全感的变化联系起来。父母的敏感性变化和 OXTRm 变化之间的交互作用对依恋随着时间的推移而发生的变化有一定的支持作用。结果表明，随着时间的推移，OXTRm在启动子区域的甲基化程度增加而在抑制剂区域的甲基化程度降低的儿童，其父母敏感性的增加与安全依恋的增加和不安全依恋的减少有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental psychobiology 生物-发育生物学

CiteScore

4.20

自引率

18.20%

发文量

125

审稿时长

6-12 weeks

期刊介绍： Developmental Psychobiology is a peer-reviewed journal that publishes original research papers from the disciplines of psychology, biology, neuroscience, and medicine that contribute to an understanding of behavior development. Research that focuses on development in the embryo/fetus, neonate, juvenile, or adult animal and multidisciplinary research that relates behavioral development to anatomy, physiology, biochemistry, genetics, or evolution is appropriate. The journal represents a broad phylogenetic perspective on behavior development by publishing studies of invertebrates, fish, birds, humans, and other animals. The journal publishes experimental and descriptive studies whether carried out in the laboratory or field. The journal also publishes review articles and theoretical papers that make important conceptual contributions. Special dedicated issues of Developmental Psychobiology , consisting of invited papers on a topic of general interest, may be arranged with the Editor-in-Chief. Developmental Psychobiology also publishes Letters to the Editor, which discuss issues of general interest or material published in the journal. Letters discussing published material may correct errors, provide clarification, or offer a different point of view. Authors should consult the editors on the preparation of these contributions.