‘Nip it in the bud’: Low-frequency rTMS of the prefrontal cortex disrupts threat memory consolidation in humans

IF 4.2 2区 心理学 Q1 PSYCHOLOGY, CLINICAL Behaviour Research and Therapy Pub Date : 2024-04-27 DOI:10.1016/j.brat.2024.104548
Simone Battaglia , Claudio Nazzi , Miquel A. Fullana , Giuseppe di Pellegrino , Sara Borgomaneri
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Abstract

It is still unclear how the human brain consolidates aversive (e.g., traumatic) memories and whether this process can be disrupted. We hypothesized that the dorsolateral prefrontal cortex (dlPFC) is crucially involved in threat memory consolidation. To test this, we used low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) within the memory stabilization time window to disrupt the expression of threat memory. We combined a differential threat-conditioning paradigm with LF-rTMS targeting the dlPFC in the critical condition, and occipital cortex stimulation, delayed dlPFC stimulation, and sham stimulation as control conditions. In the critical condition, defensive reactions to threat were reduced immediately after brain stimulation, and 1 h and 24 h later. In stark contrast, no decrease was observed in the control conditions, thus showing both the anatomical and temporal specificity of our intervention. We provide causal evidence that selectively targeting the dlPFC within the early consolidation period prevents the persistence and return of conditioned responses. Furthermore, memory disruption lasted longer than the inhibitory window created by our TMS protocol, which suggests that we influenced dlPFC neural activity and hampered the underlying, time-dependent consolidation process. These results provide important insights for future clinical applications aimed at interfering with the consolidation of aversive, threat-related memories.

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将威胁扼杀在萌芽状态对前额叶皮层进行低频经颅磁刺激可破坏人类的威胁记忆巩固
目前还不清楚人脑是如何巩固厌恶(如创伤)记忆的,也不清楚这一过程是否会被破坏。我们假设背外侧前额叶皮层(dlPFC)是威胁记忆巩固的关键。为了验证这一点,我们在记忆稳定时间窗内使用低频重复经颅磁刺激(LF-rTMS)来破坏威胁记忆的表达。我们将不同的威胁条件范式与针对dlPFC的LF-rTMS结合在一起,在临界状态下,枕叶皮层刺激、延迟dlPFC刺激和假刺激作为对照条件。在临界状态下,脑刺激后立即、1 小时后和 24 小时后,对威胁的防御反应都有所降低。与此形成鲜明对比的是,在对照组条件下没有观察到防御反应的减少,这表明我们的干预具有解剖学和时间上的特异性。我们提供的因果关系证据表明,在早期巩固期选择性地针对大脑前交叉皮质(dlPFC)进行干预可以防止条件反应的持续和恢复。此外,记忆中断持续的时间比我们的 TMS 方案所创建的抑制窗口更长,这表明我们影响了 dlPFC 的神经活动,阻碍了潜在的、随时间变化的巩固过程。这些结果为今后旨在干扰厌恶、威胁相关记忆巩固的临床应用提供了重要启示。
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来源期刊
Behaviour Research and Therapy
Behaviour Research and Therapy PSYCHOLOGY, CLINICAL-
CiteScore
7.50
自引率
7.30%
发文量
148
期刊介绍: The major focus of Behaviour Research and Therapy is an experimental psychopathology approach to understanding emotional and behavioral disorders and their prevention and treatment, using cognitive, behavioral, and psychophysiological (including neural) methods and models. This includes laboratory-based experimental studies with healthy, at risk and subclinical individuals that inform clinical application as well as studies with clinically severe samples. The following types of submissions are encouraged: theoretical reviews of mechanisms that contribute to psychopathology and that offer new treatment targets; tests of novel, mechanistically focused psychological interventions, especially ones that include theory-driven or experimentally-derived predictors, moderators and mediators; and innovations in dissemination and implementation of evidence-based practices into clinical practice in psychology and associated fields, especially those that target underlying mechanisms or focus on novel approaches to treatment delivery. In addition to traditional psychological disorders, the scope of the journal includes behavioural medicine (e.g., chronic pain). The journal will not consider manuscripts dealing primarily with measurement, psychometric analyses, and personality assessment.
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