Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Nanogel in Complete Freund’s Adjuvant-Induced Rheumatoid Arthritis (RA) Rat Model: Anti-Arthritic, Anti-Inflammatory, and Antioxidative Activity

IF 1.4 4区 生物学 Q4 MYCOLOGY International journal of medicinal mushrooms Pub Date : 2024-05-01 DOI:10.1615/intjmedmushrooms.2024053884
Nuniek Ina Ratnaningtyas, Fajar Husen, Nur Fitrianto
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Abstract

Lingzhi or reishi mushroom, Ganoderma lucidum, is a medicinal mushroom quite widely developed as herbal medicine because it has acted as an anticancer, antitumor, antioxidant, and anti-inflammatory. The active mycochemical compounds of G. lucidum mushrooms, such as flavonoids and polysaccharides, can suppress the release of pro-inflammatory cytokines and prevent lipid peroxidation due to oxidative stress. Rheumatoid arthritis (RA) is an autoimmune disease where the exact cause is unknown, and RA prevalence continues to increase yearly. In patients with RA, joint damage and inflammation occur. This study aims to evaluate the effectiveness of G. lucidum nanogels as anti-arthritis, anti-inflammatory, and antioxidative. The research method was a true experiment using a control group and treatment group that randomly assigned, using 24 male Wistar rats (Rattus norvegicus) induced with complete Freund's adjuvant (CFA) 0.1 mL. The rats were divided into six groups; healthy control/HCt (did not receive the treatment), negative control/NCt (induced by CFA), and positive control/PCt (given 0.012 diclofenac sodium). TG1 (given 250 mg G. lucidum nanogels), TG2 (given 500 mg G. lucidum nanogels), TG3 (given 750 mg G. lucidum nanogels). IgG, eNOS, IL-1β, COX-2, NOS, TNF-α, and IL-6 parameters were measured using ELISA, and the data obtained were analyzed by one-way ANOVA using SPSS (p < 0.05). The results showed that administering G. lucidum nanogels significantly reduced IgG, NOS, TNF-α, COX-2, IL-1β, and IL-6 and increased eNOS levels. The anti-inflammatory and antioxidative activities in suppressing pro-inflammatory cytokines and increasing eNOS levels prove that the nanogel ext
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灵芝或灵芝药用菌灵芝(姬松茸)纳米凝胶在完全弗氏佐剂诱导的类风湿性关节炎(RA)大鼠模型中的应用:抗关节炎、抗炎和抗氧化活性
灵芝(Ganoderma lucidum)是一种药用蘑菇,因其具有抗癌、抗肿瘤、抗氧化和抗炎作用而被广泛开发为中药材。灵芝蘑菇中的黄酮类和多糖类等活性菌类化学物质可以抑制促炎细胞因子的释放,防止氧化应激引起的脂质过氧化。类风湿性关节炎(RA)是一种自身免疫性疾病,其确切病因尚不清楚,且发病率逐年上升。类风湿性关节炎患者会出现关节损伤和炎症。本研究旨在评估绿巨人纳米凝胶作为抗关节炎、抗炎和抗氧化剂的功效。研究方法是使用 24 只雄性 Wistar 大鼠(Rattus norvegicus),以 0.1 mL 完全弗氏佐剂(CFA)诱导,通过随机分配的对照组和治疗组进行真实实验。大鼠被分为六组:健康对照组/HCt(未接受治疗)、阴性对照组/NCt(由 CFA 诱导)和阳性对照组/PCt(给予 0.012 双氯芬酸钠)。TG1(给予 250 毫克绿巨人纳米凝胶)、TG2(给予 500 毫克绿巨人纳米凝胶)、TG3(给予 750 毫克绿巨人纳米凝胶)。采用 ELISA 法测定 IgG、eNOS、IL-1β、COX-2、NOS、TNF-α 和 IL-6 参数,并采用 SPSS 进行单因素方差分析(p < 0.05)。结果表明,服用绿巨人纳米凝胶能显著降低 IgG、NOS、TNF-α、COX-2、IL-1β 和 IL-6 的水平,提高 eNOS 的水平。纳米凝胶在抑制促炎细胞因子和提高 eNOS 水平方面的抗炎和抗氧化活性证明了纳米凝胶的扩展性。
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来源期刊
CiteScore
2.60
自引率
16.70%
发文量
91
审稿时长
6-12 weeks
期刊介绍: The rapid growth of interest in medicinal mushrooms research is matched by the large number of disparate groups that currently publish in a wide range of publications. The International Journal of Medicinal Mushrooms is the one source of information that will draw together all aspects of this exciting and expanding field - a source that will keep you up to date with the latest issues and practice. The International Journal of Medicinal Mushrooms published original research articles and critical reviews on a broad range of subjects pertaining to medicinal mushrooms, including systematics, nomenclature, taxonomy, morphology, medicinal value, biotechnology, and much more.
期刊最新文献
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