Medication Exposure Patterns in Primary Care Patients Prescribed Pharmacogenetically Actionable Opioids.

IF 1.6 Q2 SOCIAL SCIENCES, INTERDISCIPLINARY Qualitative Report Pub Date : 2018-08-01 Epub Date: 2018-08-07
Mitchell R Knisely, Janet S Carpenter, Marion E Broome, Ann M Holmes, Diane Von Ah, Todd Skaar, Claire Burke Draucker
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Abstract

Current approaches to assessing medication exposure fail to capture the complexity of the phenomenon and the context in which it occurs. This study's purpose was to develop a typology of subgroups of patients who share common patterns of medication exposure. To create the typology, we used an exemplar sample of 30 patients in a large public healthcare system who had been prescribed the pharmacogenetically actionable opioids codeine or tramadol. Data related to medication exposure were drawn from large data repositories. Using a person-oriented qualitative approach, eight subgroups of patients who shared common patterns of medication exposure were identified. The subgroups had one of five opioid prescription patterns (i.e., singular, episodic, switching, sustained, multiplex), and one of three types of primary foci of medical care (i.e., pain, comorbidities, both). The findings reveal medication exposure patterns that are dynamic, multidimensional, and complex, and the typology offers an innovative approach to assessing medication exposure.

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开具可药理作用阿片类药物处方的初级保健患者的药物暴露模式。
目前评估药物暴露的方法未能捕捉到药物暴露现象的复杂性及其发生的背景。本研究的目的是对具有共同药物暴露模式的患者亚群进行分类。为了建立这种类型学,我们使用了一个大型公共医疗系统中的 30 名患者作为样本,这些患者都曾被处方过具有药物基因作用的阿片类药物可待因或曲马多。与药物接触相关的数据来自大型数据存储库。采用以人为本的定性方法,确定了八个具有共同药物暴露模式的患者亚组。这些亚组具有五种阿片类药物处方模式(即单一、偶发性、转换、持续、多重)中的一种,以及三种主要医疗重点(即疼痛、合并症、两者兼有)中的一种。研究结果揭示了动态、多维和复杂的药物暴露模式,该类型学为评估药物暴露提供了一种创新方法。
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来源期刊
Qualitative Report
Qualitative Report SOCIAL SCIENCES, INTERDISCIPLINARY-
CiteScore
2.60
自引率
18.20%
发文量
148
审稿时长
45 weeks
期刊最新文献
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