Obtaining and Studying the Antioxidant Activity and Hepatoprotective Effect of a Polymer Composition Containing Silybin

IF 0.8 Q3 Engineering Nanotechnologies in Russia Pub Date : 2024-03-23 DOI:10.1134/S263516762360061X

S. L. Kuznetsov, N. V. Gukasova, I. A. Tubasheva, V. V. Zavarzina, S. V. Aleshin, A. I. Muraveva, A. A. Lapin, V. N. Zelenkov, Yu. I. Poltavets

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Abstract

Preparations based on silybin are used as hepatoprotectors in the treatment of liver lesions of various etiologies. The main disadvantage limiting their use is low bioavailability associated with the low solubility of silybin in water. To solve this problem, numerous delivery systems are created that increase its solubility, including those based on biodegradable polymers. This study presents a method for producing a polymer composition containing silybin (PCS) based on copolymers of lactic and glycolic acids. The content of the active ingredient in the product is 5%, its entrapment efficiency in particles is more than 90%; the Z-average particle size in an aqueous suspension is about 200 nm, the polydispersity index is less than 0.2, and the zeta potential is from ‒1 to ‒5 mV. The high antioxidant activity of silybin in the polymer composition by galvanostatic coulometry, as well as in the reaction of the nonenzymatic autoxidation of adrenaline, is shown. In an in vivo study on a model of acute toxic hepatitis induced by carbon tetrachloride, the more pronounced hepatoprotective effect of PCS is found compared with free silybin.

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获得并研究含水飞蓟宾的聚合物组合物的抗氧化活性和保肝效果

摘要基于水飞蓟宾的制剂可作为保肝剂用于治疗各种病因引起的肝脏病变。限制其使用的主要缺点是水飞蓟宾在水中的溶解度较低，生物利用度较低。为解决这一问题，人们创造了许多可提高水飞蓟宾溶解度的给药系统，包括基于生物可降解聚合物的给药系统。本研究介绍了一种基于乳酸和乙醇酸共聚物的含水飞蓟宾聚合物组合物（PCS）的生产方法。产品中有效成分的含量为 5%，其在颗粒中的夹带效率超过 90%；在水悬浮液中的 Z 平均粒径约为 200 nm，多分散指数小于 0.2，zeta 电位为-1 至 -5 mV。通过电静电库仑计以及肾上腺素的非酶自氧化反应显示，聚合物成分中的水飞蓟宾具有很高的抗氧化活性。在对四氯化碳诱发的急性中毒性肝炎模型进行的体内研究中发现，与游离水飞蓟宾相比，PCS 具有更明显的保肝作用。

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来源期刊

Nanotechnologies in Russia NANOSCIENCE & NANOTECHNOLOGY-

CiteScore

1.20

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期刊介绍： Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.