Investigation of effect of ellagic acid on premature ovarian insufficiency

Abstract

One common medical condition affecting the reproductive system in older women is premature ovarian failure (POF). POF can result from radiation therapy, chemotherapy, immune system problems, infection, inflammation, and genetic mutation.The current study examined the effect of Ellagic acid on Premature Ovarian Insufficiency.The study utilized, 8-12 months old 150 ± 20 gm, 42 female wistar rats. For the induction of Premature Ovarian Insufficiency, Tripterygium Glycoside (TG) was administered at a dosage of 50 mg/ml dissolved in water for injection once daily. Clomiphene Citrate, 1 mg/kg was administered orally once daily for 21 days. Ellagic acid was given orally once daily at concentration of 10 mg/kg, 20 mg/kg, 30 mg/kg. The statistic of the data was determined by using ANOVA test.The results showed that effect of Ellagic acid on premature ovarian insufficiency as evidenced by decreased levels of cholesterol, triglycerides, follicle stimulating hormone and Luteinizing hormone and increased levels of estrogen.According to the current study, female wistar rats with Tripterygium Glycoside induced Premature Ovarian Insufficiency can benefit from treatment with an Ellagic acid.