Modern ideas about the pathogenetic mechanisms of the development of inflammatory bowel diseases

O. V. Babenko, I. Vasylyeva, N. V. Yarmysh, O. A. Nakonechna
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Abstract

The high frequency of prevalence and the decrease in the quality of life of patients determine the urgency of studying the peculiarities of the etiology and pathogenesis of inflammatory bowel diseases. The difficulty of finding new non-invasive markers lies in the lack of a clear understanding of the molecular mechanisms of the pathogenesis of these diseases. One of the promising directions in the diagnosis of chronic inflammatory diseases is the identification of specific miRNA molecules in blood serum, which act as powerful negative regulators of gene expression.
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关于炎症性肠病发病机制的现代观点
炎症性肠病的高发病率和患者生活质量的下降决定了研究炎症性肠病的病因和发病机制的紧迫性。寻找新的非侵入性标记物的困难在于对这些疾病发病的分子机制缺乏清晰的认识。诊断慢性炎症性疾病的一个有希望的方向是鉴定血清中的特定 miRNA 分子,它们是基因表达的强大负调控因子。
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