Visceral Fat-associated Adipokines and Metabolic Variables in Central Obese Type 2 Diabetic Patients

Abstract

The aim of the study was to comprehend the relationship between visceral fat-associated adipokines and biochemical variables in central obese type 2 diabetic patients. Visceral obesity is linked with insulin resistance in peripheral tissues and is an alternative risk determinant for developing type 2 diabetes mellitus. The infiltration of macrophages in the visceral fatty tissue and the unreliable generation of adipokines are associated with mechanisms directing the progress of insulin resistance. The objective of the study was to evaluate the relationship between visceral fat-associated adipokines and biochemical variables in central obese type 2 diabetic patients. Serum adipokines were analyzed by Eenzyme-Linked Immunosorbent Assay. Biochemical variables were measured using Cobas® 6000 analyzer. HbA1c was measured by High Performance Liquid Chromatography. The results show a significant relationship (p < 0.05) between the adipokines and Fasting Plasma Glucose (FPG), Postprandial Blood Glucose (PPBG) and HbA1c levels. The results indicate a significant association (p < 0.05) between the adipokines and lipid profile with varying degrees in central obese type 2 diabetic subjects. The relationship between visceral fat-associated adipokines and metabolic variables may influence the metabolic pathways in central obese type 2 diabetic patients. The adipokines are strong predictors for the intensification of type 2 diabetes mellitus and can be used as a diagnostic tool for risk assessment in the central obese population. The study provides new insight that requires further investigations and understanding of the metabolic pathways in central obese type 2 diabetic patients.