Obtaining of Nanodiamond Conjugates with Scandium Isotopes for the Use in Nuclear Medicine

IF 0.9 Q4 CHEMISTRY, INORGANIC & NUCLEAR Radiochemistry Pub Date : 2024-05-16 DOI:10.1134/S1066362224020103

A. G. Kazakov, T. Y. Ekatova, S. E. Vinokurov, E. Y. Khvorostinin, I. A. Ushakov, V. V. Zukau, E. S. Stasyuk, E. A. Nesterov, V. L. Sadkin, A. S. Rogov, B. F. Myasoedov

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Abstract

In this work, we studied the sorption of scandium, whose isotopes ⁴⁴Sc and ⁴⁷Sc are explored for diagnostics and therapy in nuclear medicine, by aggregates of commercial (TAN, STP) and oxidized nanodiamonds (ox-STP) from aqueous solutions. The sorption capacity of the studied NDs for scandium was determined; 100 μg of NDs is found to be sufficient for the sorption of 1 GBq of ⁴⁷Sc, which is equivalent to the activity of isotopes used in therapy. It was shown that the supposed mechanism for the binding of Sc(III) to nanodiamond aggregates is chemisorption, and the chemical composition of the nanodiamond surface affects the sorption efficiency to a greater extent than the speciation of scandium in solution. The obtained data on Sc(III) sorption are correlated with the sizes of nanodiamond aggregates; it is shown that sorption under experimental conditions does not depend on the size of the aggregates. For the further development of radiopharmaceuticals based on ⁴⁷Sc, optimal carriers for this isotope—TAN and ox-STP—were suggested.

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获得用于核医学的钪同位素纳米金刚石共轭物

摘要在这项工作中，我们研究了商用纳米金刚石（TAN、STP）和氧化纳米金刚石（ox-STP）聚集体从水溶液中吸附钪的情况，钪的同位素 44Sc 和 47Sc 在核医学中被用于诊断和治疗。测定了所研究的纳米金刚石对钪的吸附能力；发现 100 μg 的纳米金刚石足以吸附 1 GBq 的 47Sc，这相当于用于治疗的同位素的活性。研究表明，Sc(III)与纳米金刚石聚集体结合的假定机制是化学吸附，纳米金刚石表面的化学成分对吸附效率的影响程度大于溶液中钪的种类。所获得的 Sc(III) 吸附数据与纳米金刚石聚集体的大小相关；实验表明，实验条件下的吸附与聚集体的大小无关。为进一步开发基于 47Sc 的放射性药物，提出了该同位素的最佳载体--TAN 和 ox-STP。

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来源期刊

Radiochemistry CHEMISTRY, INORGANIC & NUCLEAR-

CiteScore

1.30

自引率

33.30%

发文量

期刊介绍： Radiochemistry is a journal that covers the theoretical and applied aspects of radiochemistry, including basic nuclear physical properties of radionuclides; chemistry of radioactive elements and their compounds; the occurrence and behavior of natural and artificial radionuclides in the environment; nuclear fuel cycle; radiochemical analysis methods and devices; production and isolation of radionuclides, synthesis of labeled compounds, new applications of radioactive tracers; radiochemical aspects of nuclear medicine; radiation chemistry and after-effects of nuclear transformations.