Effects of ketamine, propofol and isoflurane on electrocardiographic variables in clinically healthy dogs premedicated with medetomidine and midazolam.

IF 0.8 4区 农林科学 Q3 ZOOLOGY Veterinary Research Forum Pub Date : 2024-01-01 Epub Date: 2024-04-15 DOI:10.30466/vrf.2024.2008055.3954
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Abstract

The purpose of this study was to investigate the effects of three anesthetic agents, with premedication of medetomidine and midazolam, on electrocardiographic variables in dogs. Ten adult mixed breed dogs were used in a crossover design study, where they received ketamine, propofol and isoflurane treatments with a one-week washout period between them. In all three groups, medetomidine was administered first followed by midazolam after 15 min. Then, after 20 min, group 1 received ketamine intravenously (IV), group 2 received propofol (IV), and group 3 received isoflurane (inhalation). In all dogs, electrocardiographs were taken before and after premedication's, as well as every 15 min during anesthesia. Medetomidine significantly decreased heart rate and P wave amplitude and increased PR interval, R wave amplitude, QT interval, and T wave amplitude. Midazolam increased the amplitude of the R and T waves. Ketamine increased the heart rate and PR interval. Propofol increased the heart rate for up to 15 min, decreased the PR interval for up to 30 min, and the QT interval for up to 45 min. Isoflurane increased the heart rate and decreased the amplitude of R and T waves. The results showed that the drugs used in this study did not have many side effects on electrocardiographic variables and could be used without serious concern. The most important side effects observed were a severe reduction in heart rate and 1st degree atrioventricular (AV) block and, to a lesser extent, 2nd degree AV block caused by medetomidine and midazolam which were masked by the anesthetics.

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氯胺酮、异丙酚和异氟烷对使用美托咪啶和咪达唑仑进行预处理的临床健康犬心电图变量的影响。
本研究的目的是探讨三种麻醉剂在使用美托咪啶和咪达唑仑进行预处理后对狗心电图变量的影响。研究采用交叉设计,使用 10 只成年混种犬分别接受氯胺酮、异丙酚和异氟烷治疗,中间有一周的冲洗期。在所有三组中,首先使用美托咪定,15 分钟后使用咪达唑仑。然后,20 分钟后,第 1 组静脉注射氯胺酮,第 2 组静脉注射异丙酚,第 3 组吸入异氟醚。在麻醉前和麻醉后,以及麻醉期间每隔 15 分钟对所有狗进行心电图检查。美托咪啶明显降低了心率和 P 波振幅,增加了 PR 间期、R 波振幅、QT 间期和 T 波振幅。咪达唑仑增加了 R 波和 T 波的振幅。氯胺酮增加了心率和 PR 间期。丙泊酚可使心率加快达 15 分钟,PR 间期缩短达 30 分钟,QT 间期缩短达 45 分钟。异氟醚增加了心率,降低了 R 波和 T 波的振幅。结果表明,本研究中使用的药物对心电图变量的副作用不大,可以放心使用。观察到的最重要的副作用是心率严重下降和一度房室传导阻滞,其次是由美托咪定和咪达唑仑引起的二度房室传导阻滞,这些副作用都被麻醉剂所掩盖。
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来源期刊
Veterinary Research Forum
Veterinary Research Forum Veterinary-General Veterinary
CiteScore
1.50
自引率
0.00%
发文量
0
审稿时长
8 weeks
期刊介绍: Veterinary Research Forum (VRF) is a quarterly international journal committed to publish worldwide contributions on all aspects of veterinary science and medicine, including anatomy and histology, physiology and pharmacology, anatomic and clinical pathology, parasitology, microbiology, immunology and epidemiology, food hygiene, poultry science, fish and aquaculture, anesthesia and surgery, large and small animal internal medicine, large and small animal reproduction, biotechnology and diagnostic imaging of domestic, companion and farm animals.
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