Chun Tian , Fan Xu , Yu He , Hong-Lian Ai , Bao-Bao Shi , Ji-Kai Liu
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引用次数: 0
Abstract
Chemical investigation on methanol extract of the fruiting bodies of Grifola frondosa led to the isolation of seven pyrrole alkaloids and two furanone metabolites, including two undescribed ones (compounds 1 and 3). The structures were established by spectroscopic data analysis and quantum chemical calculations. The absolute configuration of 2 was established for the first time on the basis of its optical rotation and electronic circular dichroism aided with quantum calculations. Compound 1 showed the suppressive activity against the cell proliferation of LPS-induced B lymphocytes with IC50 value of 30.53 μM and Con A-induced T lymphocytes with IC50 value of 46.79 μM, respectively.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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