Are We Missing Hypothyroidism among Children with Sickle Cell Anaemia?

IF 1.5 Q3 HEALTH CARE SCIENCES & SERVICES Ethiopian Journal of Health Sciences Pub Date : 2023-11-01 DOI:10.4314/ejhs.v33i6.6
S O Akodu, A F Adekanmbi, T A Ogunlesi, M B Fetuga
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Abstract

Background: Children with sickle cell anaemia have been reported to have potential risk of hypothyroidism from chronic blood transfusions and probable thyroid tissue ischaemia. However, few studies on hypothyroidism status of children with sickle cell anaemia in Nigeria are available. The objective of this study was to determine the prevalence of hypothyroidism among children with sickle cell anaemia.

Methods: A cross sectional study that assayed the thyroid hormones and thyroid stimulating hormone (TSH) of 71 children with sickle cell anaemia was conducted at Olabisi Onabanjo University Teaching Hospital Sagamu. Using age appropriate hormonal reference values, the subjects were classified into subclinical, primary and secondary hypothyroidism.

Results: The mean serum TSH, Free T3, and Free T4 were comparable irrespective of age category (p > 0.05). No subject was identified to have low TSH value while 7.0% had high TSH value. Low free T3 was identified in 1.4% and 8.5% had high free T3 values. Low free T3 and free T4 were seen in 11.3% each of the subjects. The overall prevalence of primary, secondary and subclinical hypothyroidism was 0%, 0% and 4.2%, respectively.

Conclusion: Sub-clinical hypothyroidism does occur in Nigerian children with sickle cell anaemia. Routine screening for hypothyroidism is advocated in all children with sickle cell anaemia.

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镰状细胞性贫血患儿中是否存在甲状腺功能减退症?
背景:据报道,镰状细胞性贫血患儿因长期输血和甲状腺组织可能缺血而有甲状腺功能减退的潜在风险。然而,关于尼日利亚镰状细胞性贫血患儿甲状腺功能减退状况的研究却寥寥无几。本研究旨在确定镰状细胞贫血儿童中甲状腺功能减退症的发病率:这项横断面研究在奥拉比西-奥纳班霍大学萨加穆教学医院(Olabisi Onabanjo University Teaching Hospital Sagamu)进行,对 71 名镰状细胞贫血患儿的甲状腺激素和促甲状腺激素(TSH)进行了检测。根据与年龄相适应的激素参考值,受试者被分为亚临床、原发性和继发性甲状腺功能减退症:结果:无论年龄大小,受试者的平均血清促甲状腺激素(TSH)、游离 T3 和游离 T4 都相当(P > 0.05)。没有人发现 TSH 值偏低,而 7.0% 的人 TSH 值偏高。1.4%的受试者游离 T3 值偏低,8.5%的受试者游离 T3 值偏高。游离 T3 和游离 T4 值偏低的受试者各占 11.3%。原发性、继发性和亚临床甲减的总发病率分别为 0%、0% 和 4.2%:结论:尼日利亚镰状细胞贫血患儿中确实存在亚临床甲状腺功能减退症。建议对所有镰状细胞贫血患儿进行甲减常规筛查。
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来源期刊
Ethiopian Journal of Health Sciences
Ethiopian Journal of Health Sciences HEALTH CARE SCIENCES & SERVICES-
CiteScore
2.10
自引率
8.30%
发文量
137
审稿时长
12 weeks
期刊介绍: Ethiopian Journal of Health Sciences is a general health science journal addressing clinical medicine, public health and biomedical sciences. Rarely, it covers veterinary medicine
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