Radiofrequency enhances drug release from responsive nanoflowers for hepatocellular carcinoma therapy

IF 2.6 4区 材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Beilstein Journal of Nanotechnology Pub Date : 2024-05-22 DOI:10.3762/bjnano.15.49
Yanyan Wen, Ningning Song, Yueyou Peng, Weiwei Wu, Qixiong Lin, Minjie Cui, Rongrong Li, Qiufeng Yu, Sixue Wu, Yongkang Liang, Wei Tian, Yanfeng Meng
{"title":"Radiofrequency enhances drug release from responsive nanoflowers for hepatocellular carcinoma therapy","authors":"Yanyan Wen, Ningning Song, Yueyou Peng, Weiwei Wu, Qixiong Lin, Minjie Cui, Rongrong Li, Qiufeng Yu, Sixue Wu, Yongkang Liang, Wei Tian, Yanfeng Meng","doi":"10.3762/bjnano.15.49","DOIUrl":null,"url":null,"abstract":"Hepatocellular carcinoma (HCC) is the sixth most common malignant tumor and the third leading cause of cancer death worldwide. Most patients are diagnosed at an advanced stage, and systemic chemotherapy is the preferred treatment modality for advanced HCC. Curcumin (CUR) is a polyphenolic antineoplastic drug with low toxicity obtained from plants. However, its low bioavailability and poor solubility limit its functionality. In this study, radiofrequency- (RF) enhanced responsive nanoflowers (NFs), containing superparamagnetic ferric oxide nanoclusters (Fe3O4 NCs), – CUR layer, – and MnO2 (CUR-Fe@MnO2 NFs), were verified to have a thermal therapeutic effect. Transmission electron microscopy was used to characterize the CUR-Fe@MnO2 NFs, which appeared flower-like with a size of 96.27 nm. The in vitro experimental data showed that RF enhanced the degradation of CUR-Fe@MnO2 NFs to release Mn2+ and CUR. The cytotoxicity test results indicated that after RF heating, the CUR-Fe@MnO2 NFs significantly suppressed HCC cell proliferation. Moreover, CUR-Fe@MnO2 NFs were effective T1/T2 contrast agents for molecular magnetic resonance imaging due to the release of Mn2+ and Fe3O4 NCs.","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":null,"pages":null},"PeriodicalIF":2.6000,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Beilstein Journal of Nanotechnology","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.3762/bjnano.15.49","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

Hepatocellular carcinoma (HCC) is the sixth most common malignant tumor and the third leading cause of cancer death worldwide. Most patients are diagnosed at an advanced stage, and systemic chemotherapy is the preferred treatment modality for advanced HCC. Curcumin (CUR) is a polyphenolic antineoplastic drug with low toxicity obtained from plants. However, its low bioavailability and poor solubility limit its functionality. In this study, radiofrequency- (RF) enhanced responsive nanoflowers (NFs), containing superparamagnetic ferric oxide nanoclusters (Fe3O4 NCs), – CUR layer, – and MnO2 (CUR-Fe@MnO2 NFs), were verified to have a thermal therapeutic effect. Transmission electron microscopy was used to characterize the CUR-Fe@MnO2 NFs, which appeared flower-like with a size of 96.27 nm. The in vitro experimental data showed that RF enhanced the degradation of CUR-Fe@MnO2 NFs to release Mn2+ and CUR. The cytotoxicity test results indicated that after RF heating, the CUR-Fe@MnO2 NFs significantly suppressed HCC cell proliferation. Moreover, CUR-Fe@MnO2 NFs were effective T1/T2 contrast agents for molecular magnetic resonance imaging due to the release of Mn2+ and Fe3O4 NCs.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
射频增强响应性纳米花的药物释放,用于肝癌治疗
肝细胞癌(HCC)是全球第六大常见恶性肿瘤和第三大癌症死因。大多数患者确诊时已是晚期,全身化疗是晚期 HCC 的首选治疗方式。姜黄素(CUR)是从植物中提取的低毒多酚抗肿瘤药物。然而,其生物利用度低和溶解性差限制了其功能的发挥。在这项研究中,包含超顺磁性氧化铁纳米团簇(Fe3O4 NCs)、CUR 层和 MnO2(CUR-Fe@MnO2 NFs)的射频(RF)增强型响应纳米花(NFs)被证实具有热疗效果。透射电子显微镜对 CUR-Fe@MnO2 NFs 进行了表征,CUR-Fe@MnO2 NFs 呈花朵状,大小为 96.27 nm。体外实验数据显示,射频增强了 CUR-Fe@MnO2 NFs 的降解,释放出 Mn2+ 和 CUR。细胞毒性测试结果表明,射频加热后,CUR-Fe@MnO2 NFs 能显著抑制 HCC 细胞的增殖。此外,由于释放了 Mn2+ 和 Fe3O4 NCs,CUR-Fe@MnO2 NFs 成为分子磁共振成像中有效的 T1/T2 造影剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Beilstein Journal of Nanotechnology
Beilstein Journal of Nanotechnology NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY
CiteScore
5.70
自引率
3.20%
发文量
109
审稿时长
2 months
期刊介绍: The Beilstein Journal of Nanotechnology is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in nanoscience and nanotechnology. The journal is published and completely funded by the Beilstein-Institut, a non-profit foundation located in Frankfurt am Main, Germany. The editor-in-chief is Professor Thomas Schimmel – Karlsruhe Institute of Technology. He is supported by more than 20 associate editors who are responsible for a particular subject area within the scope of the journal.
期刊最新文献
New design of operational MEMS bridges for measurements of properties of FEBID-based nanostructures. Functional morphology of cleaning devices in the damselfly Ischnura elegans (Odonata, Coenagrionidae). The role of a tantalum interlayer in enhancing the properties of Fe3O4 thin films. Dual-functionalized architecture enables stable and tumor cell-specific SiO2NPs in complex biological fluids. Enhanced catalytic reduction through in situ synthesized gold nanoparticles embedded in glucosamine/alginate nanocomposites.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1