Mushrooms and Their Compounds with Potential Anticancer Activity: A Review

IF 1.4 4区 生物学 Q4 MYCOLOGY International journal of medicinal mushrooms Pub Date : 2024-05-01 DOI:10.1615/intjmedmushrooms.2024054163
Maura Téllez Téllez, Gerardo Díaz-Godínez
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Abstract

Mushrooms produce many metabolites that show biological activity, which can be obtained from their fruiting body, mycelium or recovered from the culture broth when mushrooms are grown in submerged fermentation. Mushrooms are a source of natural pharmaceuticals, they have been reported to have potential inhibitory or preventive activity against some diseases, including different types of cancer. Cancer represents one of the main causes of death worldwide. It is worth mentioning that despite advances in pharmacological treatments, they still present side effects in patients. In this sense, the study of the use of mushrooms in complementary treatments against cancer is of great interest. Based on studies carried out in vitro and, in some cases, using animal models, it has been observed that mushrooms present preventive, corrective, and therapeutic properties against different types of cancer, by stimulating the immune system, due to their antioxidant, antimutagenic, and anti-inflammatory activities, as well as the regulation of the expression of some cellular processes, cell cycle arrest, and apoptosis, etc. Based on the above, this manuscript shows a review of scientific studies that support the anticancer activity of some mushrooms and/or their bioactive compounds.
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具有潜在抗癌活性的蘑菇及其化合物:综述
蘑菇会产生许多具有生物活性的代谢物,这些代谢物可以从蘑菇的子实体、菌丝体中获得,也可以在浸没发酵法种植蘑菇时从培养液中回收。蘑菇是天然药物的一种来源,据报道,它们对某些疾病(包括不同类型的癌症)具有潜在的抑制或预防活性。癌症是全球死亡的主要原因之一。值得一提的是,尽管药物治疗取得了进步,但仍会对患者产生副作用。从这个意义上说,研究蘑菇在癌症辅助治疗中的应用意义重大。根据在体外进行的研究,以及在某些情况下使用动物模型进行的研究,我们发现蘑菇具有抗氧化、抗突变、抗炎以及调节某些细胞过程的表达、细胞周期停滞和细胞凋亡等作用,通过刺激免疫系统,对不同类型的癌症具有预防、纠正和治疗作用。综上所述,本手稿回顾了支持某些蘑菇和/或其生物活性化合物抗癌活性的科学研究。
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来源期刊
CiteScore
2.60
自引率
16.70%
发文量
91
审稿时长
6-12 weeks
期刊介绍: The rapid growth of interest in medicinal mushrooms research is matched by the large number of disparate groups that currently publish in a wide range of publications. The International Journal of Medicinal Mushrooms is the one source of information that will draw together all aspects of this exciting and expanding field - a source that will keep you up to date with the latest issues and practice. The International Journal of Medicinal Mushrooms published original research articles and critical reviews on a broad range of subjects pertaining to medicinal mushrooms, including systematics, nomenclature, taxonomy, morphology, medicinal value, biotechnology, and much more.
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