A review on manufacturing processes of cobalt-chromium alloy implants and its impact on corrosion resistance and biocompatibility

IF 3.2 4区 医学 Q2 ENGINEERING, BIOMEDICAL Journal of biomedical materials research. Part B, Applied biomaterials Pub Date : 2024-05-30 DOI:10.1002/jbm.b.35431
Gopinath Mani, Deanna Porter, Shell Collins, Tim Schatz, Andreas Ornberg, Robert Shulfer
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Abstract

Cobalt-Chromium (CoCr) alloys are currently used for various cardiovascular, orthopedic, fracture fixation, and dental implants. A variety of processes such as casting, forging, wrought processing, hot isostatic pressing, metal injection molding, milling, selective laser melting, and electron beam melting are used in the manufacture of CoCr alloy implants. The microstructure and precipitates (carbides, nitrides, carbonitrides, and intermetallic compounds) formed within the alloy are primarily determined by the type of manufacturing process employed. Although the effects of microstructure and precipitates on the physical and mechanical properties of CoCr alloys are well reviewed and documented in the literature, the effects on corrosion resistance and biocompatibility are not comprehensively reviewed. This article reviews the various processes used to manufacture CoCr alloy implants and discusses the effects of manufacturing processes on corrosion resistance and biocompatibility. This review concludes that the microstructure and precipitates formed in the alloy are unique to the manufacturing process employed and have a significant impact on the corrosion resistance and biocompatibility of CoCr alloys. Additionally, a historical and scientific overview of corrosion and biocompatibility for metallic implants is included in this review. Specifically, the failure of CoCr alloys when used in metal-on-metal bearing surfaces of total hip replacements is highlighted. It is recommended that the type of implant/application (orthopedic, dental, cardiovascular, etc.) should be the first and foremost factor to be considered when selecting biomaterials for medical device development.

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钴铬合金植入体制造工艺及其对耐腐蚀性和生物相容性的影响综述。
钴铬(CoCr)合金目前用于各种心血管、整形外科、骨折固定和牙科植入物。钴铬合金植入体的制造工艺多种多样,如铸造、锻造、锻造加工、热等静压、金属注射成型、铣削、选择性激光熔化和电子束熔化等。合金内部形成的微观结构和沉淀物(碳化物、氮化物、碳氮化物和金属间化合物)主要取决于所采用的制造工艺类型。虽然微观结构和沉淀物对 CoCr 合金物理和机械性能的影响已在文献中进行了详细的评述和记录,但对耐腐蚀性和生物相容性的影响却没有进行全面的评述。本文回顾了用于制造 CoCr 合金植入体的各种工艺,并讨论了制造工艺对耐腐蚀性和生物相容性的影响。综述认为,合金中形成的微观结构和沉淀物是所采用的制造工艺所独有的,对 CoCr 合金的耐腐蚀性和生物相容性有重大影响。此外,本综述还对金属植入物的腐蚀性和生物相容性进行了历史和科学概述。特别强调了钴铬合金在用于全髋关节置换术的金属对金属轴承表面时的失效情况。建议在为医疗器械开发选择生物材料时,植入物的类型/应用(骨科、牙科、心血管等)应作为首要考虑因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.50
自引率
2.90%
发文量
199
审稿时长
12 months
期刊介绍: Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.
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