Flavonoids as Potential Therapeutics Against Neurodegenerative Disorders: Unlocking the Prospects

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Neurochemical Research Pub Date : 2024-06-01 DOI:10.1007/s11064-024-04177-x

Md. Faysal, Zerrouki Dehbia, Mehrukh Zehravi, Sherouk Hussein Sweilam, M. Akiful Haque, Kusuma Praveen Kumar, Rita D. Chakole, Satish P. Shelke, Swapna Sirikonda, Mohamed H. Nafady, Sharuk L. Khan, Firzan Nainu, Irfan Ahmad, Talha Bin Emran

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Abstract

Neurodegeneration, the decline of nerve cells in the brain, is a common feature of neurodegenerative disorders (NDDs). Oxidative stress, a key factor in NDDs such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease can lead to neuronal cell death, mitochondria impairment, excitotoxicity, and Ca²⁺ stress. Environmental factors compromising stress response lead to cell damage, necessitating novel therapeutics for preventing or treating brain disorders in older individuals and an aging population. Synthetic medications offer symptomatic benefits but can have adverse effects. This research explores the potential of flavonoids derived from plants in treating NDDs. Flavonoids compounds, have been studied for their potential to enter the brain and treat NDDs. These compounds have diverse biological effects and are currently being explored for their potential in the treatment of central nervous system disorders. Flavonoids have various beneficial effects, including antiviral, anti-allergic, antiplatelet, anti-inflammatory, anti-tumor, anti-apoptotic, and antioxidant properties. Their potential to alleviate symptoms of NDDs is significant.

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黄酮类化合物是治疗神经退行性疾病的潜在药物：开启前景。

神经退行性变（脑神经细胞衰退）是神经退行性疾病（NDDs）的共同特征。氧化应激是阿尔茨海默病、帕金森病、肌萎缩性脊髓侧索硬化症和亨廷顿病等神经退行性疾病的一个关键因素，可导致神经细胞死亡、线粒体受损、兴奋毒性和 Ca2+ 应激。损害应激反应的环境因素会导致细胞损伤，因此需要新型疗法来预防或治疗老年人和老龄化人群的脑部疾病。合成药物可对症治疗，但也可能产生不良影响。这项研究探讨了从植物中提取的类黄酮在治疗 NDD 方面的潜力。黄酮类化合物因其进入大脑和治疗 NDD 的潜力而受到研究。这些化合物具有多种生物效应，目前正在探索其治疗中枢神经系统疾病的潜力。类黄酮具有多种有益作用，包括抗病毒、抗过敏、抗血小板、抗炎、抗肿瘤、抗细胞凋亡和抗氧化特性。它们在缓解非传染性疾病症状方面的潜力巨大。

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来源期刊

Neurochemical Research 医学-神经科学

CiteScore

7.70

自引率

2.30%

发文量

320

审稿时长

6 months

期刊介绍： Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.