{"title":"Detection of ciprofloxacin in ear drop using UV spectrophotometric method based on gold nanoparticles as a sensing probe","authors":"Cigdem Cicek, Zehra O. Erdogan","doi":"10.1007/s11051-024-06027-x","DOIUrl":null,"url":null,"abstract":"<p>Ciprofloxacin is a fluoroquinolone group antibiotic used to treat variety of bacterial illnesses. The purpose of this study is to develop a rapid and accurate spectrophotometric approach for the detection of ciprofloxacin using gold nanoparticles (GNPs). Localized surface plasmon resonance (LSPR) absorption band of GNPs at 523.0 nm was utilized as the spectrophotometric detection of ciprofloxacin. To determine the optimum GNPs concentration and pH value of the phosphate buffer solution used in the experimental research, the effect of pH values and GNPs concentrations in the absorbance value of ciprofloxacin-GNPs was investigated. The linear operating range for the developed spectrophotometric method was 0.015–1.48 µg/mL in pH 7.0 phosphate buffer solution. In the recovery study conducted to detect the amount of ciprofloxacin in commercial ear drops, the recovery value was calculated as 91.06 ± 1.21%.</p><h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>\n","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nanoparticle Research","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1007/s11051-024-06027-x","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Ciprofloxacin is a fluoroquinolone group antibiotic used to treat variety of bacterial illnesses. The purpose of this study is to develop a rapid and accurate spectrophotometric approach for the detection of ciprofloxacin using gold nanoparticles (GNPs). Localized surface plasmon resonance (LSPR) absorption band of GNPs at 523.0 nm was utilized as the spectrophotometric detection of ciprofloxacin. To determine the optimum GNPs concentration and pH value of the phosphate buffer solution used in the experimental research, the effect of pH values and GNPs concentrations in the absorbance value of ciprofloxacin-GNPs was investigated. The linear operating range for the developed spectrophotometric method was 0.015–1.48 µg/mL in pH 7.0 phosphate buffer solution. In the recovery study conducted to detect the amount of ciprofloxacin in commercial ear drops, the recovery value was calculated as 91.06 ± 1.21%.
期刊介绍：
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.
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