Risk of central line-associated bloodstream infections during COVID-19 pandemic in intensive care patients in a tertiary care centre in Saudi Arabia.

IF 2.5 4区 医学 Q3 INFECTIOUS DISEASES Epidemiology and Infection Pub Date : 2024-06-03 DOI:10.1017/S0950268824000736
Majid M Alshamrani, Aiman El-Saed, Omar Aldayhani, Abdulaziz Alhassan, Abdullah Alhamoudi, Mohammed Alsultan, Mohammed Alrasheed, Fatmah Othman
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Abstract

This retrospective study compared central line-associated bloodstream infection (CLABSI) rates per 1 000 central line days, and overall mortality before and during the COVID-19 pandemic in adult, paediatric, and neonatal ICU patients at King Abdul-Aziz Medical City-Riyadh who had a central line and were diagnosed with CLABSI according to the National Healthcare Safety Network standard definition. The study spanned between January 2018 and December 2019 (pre-pandemic), and January 2020 and December 2021 (pandemic). SARS-CoV-2 was confirmed by positive RT-PCR testing. The study included 156 CLABSI events and 46 406 central line days; 52 and 22 447 (respectively) in pre-pandemic, and 104 and 23 959 (respectively) during the pandemic. CLABSI rates increased by 2.02 per 1 000 central line days during the pandemic period (from 2.32 to 4.34, p < 0.001). Likewise, overall mortality rates increased by 0.86 per 1 000 patient days (from 0.93 to 1.79, p = 0.003). Both CLABSI rates (6.18 vs. 3.7, p = 0.006) and overall mortality (2.72 vs. 1.47, p = 0.014) were higher among COVID-19 patients compared to non-COVID-19 patients. The pandemic was associated with a substantial increase in CLABSI-associated morbidity and mortality.

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沙特阿拉伯一家三级医疗中心的重症监护患者在 COVID-19 大流行期间发生中心静脉相关血流感染 (CLABSI) 的风险。
这项回顾性研究比较了利雅得阿卜杜勒-阿齐兹国王医疗城的成人、儿科和新生儿 ICU 患者在 COVID-19 大流行之前和期间每 1000 个中心管路日的中心管路相关血流感染(CLABSI)率和总死亡率,根据国家医疗安全网的标准定义,这些患者均使用了中心管路并被诊断为 CLABSI。研究时间跨度为 2018 年 1 月至 2019 年 12 月(大流行前)和 2020 年 1 月至 2021 年 12 月(大流行)。SARS-CoV-2通过阳性RT-PCR检测得到确认。研究包括 156 起 CLABSI 事件和 46 406 个中心管路日;大流行前分别为 52 起和 22 447 个,大流行期间分别为 104 起和 23 959 个。大流行期间,每千个中心管路日的 CLABSI 感染率增加了 2.02(从 2.32 增加到 4.34,P = 0.003)。与非 COVID-19 患者相比,COVID-19 患者的 CLABSI 感染率(6.18 vs. 3.7,p = 0.006)和总死亡率(2.72 vs. 1.47,p = 0.014)均较高。大流行导致 CLABSI 相关发病率和死亡率大幅上升。
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来源期刊
Epidemiology and Infection
Epidemiology and Infection 医学-传染病学
CiteScore
4.10
自引率
2.40%
发文量
366
审稿时长
3-6 weeks
期刊介绍: Epidemiology & Infection publishes original reports and reviews on all aspects of infection in humans and animals. Particular emphasis is given to the epidemiology, prevention and control of infectious diseases. The scope covers the zoonoses, outbreaks, food hygiene, vaccine studies, statistics and the clinical, social and public-health aspects of infectious disease, as well as some tropical infections. It has become the key international periodical in which to find the latest reports on recently discovered infections and new technology. For those concerned with policy and planning for the control of infections, the papers on mathematical modelling of epidemics caused by historical, current and emergent infections are of particular value.
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