Usefulness of 99mTc pyrophosphate bone scintigraphy in the survey of dialysis osteodystrophy.

Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress Pub Date : 1985-01-01

J L Vanherweghem, A Schoutens, P Bergman, M Dhaene, M Goldman, M Fuss, P Kinnaert

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Abstract

Fogelman's score (FS) was used to determine the usefulness of 99mTc pyrophosphate (Tc-PP) bone scintigraphy in the evaluation of dialysis osteodystrophy. FS correlated well with bone 47Ca accretion rate. It remained stable after six months in patients treated with 1 alpha (OH)D3 and increased significantly in a randomised group of untreated patients. It decreased after two years of 1 alpha (OH)D3 therapy while serum calcium increased and iPTH and alkaline phosphatases decreased. Patients with low FS, treated by 1 alpha (OH)D3, rapidly developed hypercalcaemia. In cases of spontaneous hypercalcaemia, parathyroidectomy did not normalise serum calcium in patients with low FS despite a significant decrease in serum iPTH. Lower FS were associated with a higher increase in serum aluminium after desferrioxamine (DFO) administration and in two cases of proven aluminium osteomalacia, DFO therapy was followed by a dramatic increase in FS.

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99mTc焦磷酸盐骨显像在透析性骨营养不良调查中的应用。

使用Fogelman评分(FS)来确定99mTc焦磷酸盐(Tc-PP)骨显像在评估透析性骨营养不良中的有效性。FS与骨47Ca增生率相关性较好。接受1 α (OH)D3治疗的患者在6个月后保持稳定，而在随机分组的未接受治疗的患者中则显著增加。1 α (OH)D3治疗2年后下降，血清钙升高，iPTH和碱性磷酸酶下降。低FS患者经1 α (OH)D3治疗后，迅速发展为高钙血症。在自发性高钙血症的病例中，甲状旁腺切除术并没有使低FS患者的血清钙正常化，尽管血清iPTH显著降低。较低的FS与使用去铁胺(DFO)后血清铝的较高升高有关，在两例证实为铝骨软化的病例中，DFO治疗后FS急剧增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress

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