Histopathological and Biochemical Alterations in the Adrenal Gland of Male Rats Exposed to Bisphenol F

IF 0.5 4区生物学 Q4 BIOLOGY Biology Bulletin Pub Date : 2024-05-31 DOI:10.1134/s1062359023606717

B. Kaptaner, A. Doğan, C. Yılmaz, H. Aykut, E. Doğan, C. Fidan Babat, F. Dönmez

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Abstract

Bisphenol F (BPF) is a bisphenol A derivative that is widely used in the manufacturing of industrial and consumer products. The presented study was conducted to explore the adverse effects of BPF on the adrenal glands of rats. Toward this aim, twenty-eight male albino Wistar rats were randomly divided into four groups, each containing seven individuals. The animals were administered a vehicle (control) or BPF at 3 different doses comprising 20, 100, and 500 mg/kg of body weight (bw) via oral gavage for 28 days. Next, the effects of BPF on the gland were evaluated in terms of histopathological alterations, serum adrenocorticotropic hormone (ACTH) and cortisol levels, and the contents of reduced glutathione (GSH) and malondialdehyde (MDA). The zona fasciculata of the adrenal cortex showed prominent histopathological lesions such as vacuolar degeneration and necrotic degeneration in the experimental groups. BPF caused noticeable elevations in the serum ACTH and cortisol levels. Moreover, decreases in levels of GSH and increments in the contents of MDA were determined, indicating oxidative stress. In conclusion, BPF showed toxic effects on the adrenal gland that may result in disruptions in its vital functions in the body. The results herein suggest that attention should be paid to the utilization of BPF in manufacturing processes due to its harmful effects and risks to the health of organisms.

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暴露于双酚 F 的雄性大鼠肾上腺的组织病理学和生化变化

摘要双酚 F（BPF）是一种双酚 A 衍生物，广泛用于制造工业产品和消费品。本研究旨在探讨 BPF 对大鼠肾上腺的不良影响。为此，研究人员将 28 只雄性白化 Wistar 大鼠随机分为四组，每组七只。这些动物通过口服给药器（对照组）或 BPF，剂量分别为 20、100 和 500 毫克/千克体重（bw），持续 28 天。然后，从组织病理学改变、血清促肾上腺皮质激素（ACTH）和皮质醇水平、还原型谷胱甘肽（GSH）和丙二醛（MDA）含量等方面评估了 BPF 对腺体的影响。在实验组中，肾上腺皮质的筋膜区出现了明显的组织病理学病变，如空泡变性和坏死变性。BPF 导致血清促肾上腺皮质激素和皮质醇水平明显升高。此外，还检测到 GSH 水平下降和 MDA 含量增加，表明存在氧化应激。总之，BPF 对肾上腺有毒性作用，可能会破坏其在体内的重要功能。研究结果表明，在生产过程中使用 BPF 时应注意其对生物体健康的有害影响和风险。

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来源期刊

Biology Bulletin 生物-生物学

CiteScore

0.70

自引率

20.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Biology Bulletin (Izvestiya Rossiiskoi Akademii Nauk – Seriya Biologicheskaya) is an interdisciplinary journal of general biology. It focuses on fundamental studies in the fields of cell biology, biochemistry, zoology, botany, physiology, and ecology. This journal publishes current materials of experimental studies and surveys on current problems in general biology. It also publishes information on scientific conferences and new books in the fields of general biology.