Understanding Benign Breast Disease and Subsequent Breast Cancer in Hispanic White Females: A Step Closer to Evidence-Based Management.

IF 3.7 3区医学 Q2 ONCOLOGY Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-08-01 DOI:10.1158/1055-9965.EPI-24-0204

Kush R Lohani, Andrea M Nibbe, Robert A Vierkant, Laura M Pacheco-Spann, Lisa R Seymour, Celine M Vachon, Mark E Sherman, Stacey J Winham, Amy C Degnim, Deirdre A Hill

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Abstract

Introduction: Although Hispanic White (HW) females have a lower incidence of breast cancer than non-Hispanic White (NHW) females, breast cancer risk is unclear for HW females after benign breast disease (BBD).

Methods: We compared BBD characteristics and subsequent breast cancer risk among HW and NHW females in New Mexico using a population-based collection of benign breast biopsies (1996-2007). BBD was categorized as nonproliferative disease (NPD), proliferative disease without atypia (PDWA), or atypical hyperplasia (AH). Breast cancer risk was assessed as absolute risk (AR) using cumulative incidence and RR by comparing the number of breast cancer events in BBDs to non-BBD.

Results: This study included 3,684 HW and 6,587 NHW females with BBD. HW females had similar proportions of NPD (58.6% vs. 54.3%), PDWA (21.4% vs. 23.5%), and AH (3.6% vs. 3.3%) as NHW females. Breast cancer risk among all females with BBD was higher than population-based expected rates (RR, 1.87) and was similar for HW and NHW subgroups (RR = 1.99 vs. 1.84). As expected, breast cancer risk increased with increasing BBD severity, both overall [RR, 1.81 (NPD), 1.85 (PDWA), and 3.10 (AH)] and in the HW and NHW subgroups. Adjusted AR of breast cancer at 5 years also increased with the severity of BBD (HW vs. NHW; NPD: 1.4% vs. 2.1%; PDWA: 1.5% vs. 2.7%; AH: 6% vs. 4.8%).

Conclusions: We found similar breast cancer RRs and ARs in HW and NHW. Risk counseling should ensure that HW females receive breast cancer clinical management warranted by their similar absolute risks.

Impact: The present population-based provides evidence for the clinical management of HW females with BBD for the prevention of breast cancer.

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了解西班牙裔白人女性的良性乳腺疾病及其后的乳腺癌；向循证管理迈进了一步。

背景西班牙裔白人女性（HW）的乳腺癌（BC）发病率低于非西班牙裔白人女性（NHW），但HW女性患良性乳腺疾病（BBD）后的BC风险尚不清楚。方法我们通过基于人群的良性乳腺活检收集（1996-2007 年），比较了新墨西哥州华裔女性和非西语裔白人女性的良性乳腺疾病特征及其后的乳腺癌风险。BBD分为非增生性疾病（NPD）、无不典型性的增生性疾病（PDWA）或非典型性增生（AH）。BC风险的评估方式包括：使用累积发病率评估绝对风险（AR）；通过比较BBD与非BBD的BC事件数量评估相对风险（RR）。结果这项研究包括 3,684 名患有 BBD 的 HW 女性和 6,587 名患有 BBD 的 NHW 女性。HW女性中NPD（58.6%vs.54.3%）、PDWA（21.4%vs.23.5%）和AH（3.6%vs.3.3%）的比例与NHW相似。在所有患有 BBD 的女性中，BC 风险高于基于人群的预期比率（RR=1.87），而在 HW 和 NHW 亚群中，BC 风险相似（RR=1.99vs.1.84）。正如预期的那样，随着BBD严重程度的增加，BC风险也会增加，无论是在总体上[RR=1.81（NPD）、1.85（PDWA）和3.10（AH）]，还是在HW和NHW亚组中。5年后BC的调整AR也随着BBD严重程度的增加而增加（HW vs. NHW；NPD：1.4 vs. 2.1%；PDWA：1.5 vs. 2.7%；AH：6 vs. 4.8%）。结论我们发现 HW 和 NHW 的 BC RRs 和 ARs 相似。风险咨询应确保女性高危人群接受与其绝对风险相似的乳腺癌临床治疗。影响本研究以人群为基础，提供了对患有 BBD 的华裔女性进行临床管理以预防乳腺癌的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

2.60%

发文量

538

审稿时长

1.6 months

期刊介绍： Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.