Polygenic risk score, healthy lifestyle score, and colorectal cancer risk: a prospective cohort study.

IF 3.7 3区医学 Q2 ONCOLOGY Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-11-21 DOI:10.1158/1055-9965.EPI-24-1013

Yuefan Shen, Weiwei Chen, Chengqu Fu, Xinyi Liu, Junyan Miao, Jiacong Li, Ni Li, Dong Hang

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Abstract

Background: Both genetic factors and lifestyle play a critical role in colorectal cancer (CRC), but the extent to which an increased genetic risk can be offset by a healthy lifestyle remains unclear.

Methods: We included 51,171 participants from the PLCO cohort. A polygenic risk score was created based on 205 genetic variants associated with CRC, and a healthy lifestyle score was constructed based on six lifestyle factors. Cox regression models were used to evaluate the association of genetic and lifestyle factors with CRC incidence.

Results: Compared with individuals at low genetic risk (the lowest 20%), those with intermediate genetic risk (20%-80%) and high genetic risk (the highest 20%) had a significantly increased risk of CRC (HR = 1.71 and 2.52, respectively). Compared with participants with a favorable lifestyle (scoring 4-6), those with an unfavorable lifestyle (scoring 0 or 1) had a 47% higher risk of CRC. Moreover, participants with a high genetic risk and a favorable lifestyle had a 45% lower risk of CRC than those with a high genetic risk and an unfavorable lifestyle, with their 10-year absolute risks of 1.29% and 2.07%, respectively.

Conclusions: Our findings suggest that adherence to a healthy lifestyle holds promise to reduce the genetic impact on CRC risk.

Impact: This study indicates that modifiable lifestyle play an important role in CRC prevention, providing new insights for personalized prevention strategies.

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多基因风险评分、健康生活方式评分与结直肠癌风险：一项前瞻性队列研究。

背景：遗传因素和生活方式在结直肠癌（CRC）中都起着至关重要的作用：遗传因素和生活方式在结直肠癌（CRC）中都起着至关重要的作用，但健康的生活方式能在多大程度上抵消遗传风险的增加仍不清楚：我们纳入了 PLCO 队列中的 51 171 名参与者。方法：我们纳入了 PLCO 队列中的 51,171 名参与者，根据与 CRC 相关的 205 个基因变异建立了多基因风险评分，并根据六个生活方式因素建立了健康生活方式评分。采用 Cox 回归模型评估遗传和生活方式因素与 CRC 发病率的关系：结果：与低遗传风险（最低的 20%）的人相比，中等遗传风险（20%-80%）和高遗传风险（最高的 20%）的人患 CRC 的风险显著增加（HR = 1.71 和 2.52）。与生活方式良好（4-6 分）的参与者相比，生活方式不良（0 分或 1 分）的参与者患 CRC 的风险高出 47%。此外，遗传风险高且生活方式良好的参与者患 CRC 的风险比遗传风险高且生活方式不良的参与者低 45%，其 10 年绝对风险分别为 1.29% 和 2.07%：我们的研究结果表明，坚持健康的生活方式有望降低遗传对 CRC 风险的影响：这项研究表明，可改变的生活方式在预防 CRC 中发挥着重要作用，为个性化预防策略提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

2.60%

发文量

538

审稿时长

1.6 months

期刊介绍： Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.