Management of Subclinical Hypothyroidism: The 2023 Korean Thyroid Association Guidelines

Hyun-Kyung Chung
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Abstract

Subclinical hypothyroidism (SCH) is characterized by elevated serum thyroid-stimulating hormone (TSH) levels and normal free thyroxine levels. The Korean Thyroid Association recently issued guidelines for managing SCH. Based on the Korea National Health and Nutrition Examination Survey (2013-2015), a serum TSH level of 6.8 mIU/L is the reference value for SCH. SCH is classified as mild (TSH 6.8-10.0 mIU/L) or severe (TSH > 10.0 mIU/L), and patients are categorized as adult (age < 70 years) or elderly (age ≥ 70 years). Levothyroxine treatment (LT4-Tx) is not recommended for mild or even severe SCH in elderly patients. Immediate LT4-Tx can be given to adults in most cases, but not to women who are pregnant, patients with progressive disease, or patients with underlying coronary artery disease, heart failure, or dyslipidemia.
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亚临床甲减的管理:2023 年韩国甲状腺协会指南
亚临床甲状腺功能减退症(SCH)的特点是血清促甲状腺激素(TSH)水平升高,而游离甲状腺素水平正常。韩国甲状腺协会最近发布了管理亚临床甲减的指南。根据韩国国民健康与营养调查(2013-2015 年),血清促甲状腺激素水平为 6.8 mIU/L 是 SCH 的参考值。SCH分为轻度(促甲状腺激素6.8-10.0 mIU/L)和重度(促甲状腺激素>10.0 mIU/L),患者分为成人(年龄<70岁)和老年人(年龄≥70岁)。对于老年患者的轻度甚至重度 SCH,不建议使用左旋甲状腺素治疗(LT4-Tx)。大多数情况下,成人可立即服用左旋甲状腺素,但妊娠期妇女、疾病进展期患者或患有潜在冠状动脉疾病、心力衰竭或血脂异常的患者不能服用。
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