Towards continuous potentiometric enzymatic biosensors

IF 7.9 2区化学 Q1 CHEMISTRY, PHYSICAL Current Opinion in Electrochemistry Pub Date : 2024-06-04 DOI:10.1016/j.coelec.2024.101549

Xinxin Xiao , Jens Ulstrup

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Abstract

Self-management of health and disease control using implantable biosensors is presently evolving strongly. Implantable biosensors require high selectivity and sensitivity, robust stability, temporal resolution, and device miniaturization. Electrochemical enzymatic biosensors that utilize specifically selective enzymes to convert the concentration of biomarker metabolites into electrochemical signals hold great promise to meet these criteria. As for electrochemical enzyme biosensors in continuous glucose monitoring, which have enjoyed great commercial success, amperometric biosensors have so far dominated enzymatic biosensor research and development. Potentiometric enzymatic biosensor research is, however, emerging with increasing strength, in particular due to greater promise for miniaturization. This minireview focuses on how to empower potentiometric enzymatic biosensors with high temporal resolution for continuous in situ monitoring of metabolites using the innovative non-equilibrium approach.

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开发连续电位计酶生物传感器

目前，利用植入式生物传感器进行自我健康管理和疾病控制的发展势头强劲。植入式生物传感器要求具有高选择性、高灵敏度、高稳定性、高时间分辨率和设备微型化。电化学酶生物传感器利用特异选择性酶将生物标记代谢物的浓度转化为电化学信号，在满足这些标准方面大有可为。电化学酶生物传感器在连续葡萄糖监测领域取得了巨大的商业成功，而迄今为止，安培酶生物传感器一直主导着酶生物传感器的研究和开发。然而，电位计酶生物传感器的研究正日益兴起，特别是由于其微型化前景更为广阔。本微型综述将重点介绍如何利用创新的非平衡方法，赋予电位计酶生物传感器高时间分辨率，以实现对代谢物的连续原位监测。

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来源期刊

Current Opinion in Electrochemistry Chemistry-Analytical Chemistry

CiteScore

14.00

自引率

5.90%

发文量

272

审稿时长

73 days

期刊介绍： The development of the Current Opinion journals stemmed from the acknowledgment of the growing challenge for specialists to stay abreast of the expanding volume of information within their field. In Current Opinion in Electrochemistry, they help the reader by providing in a systematic manner: 1.The views of experts on current advances in electrochemistry in a clear and readable form. 2.Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. In the realm of electrochemistry, the subject is divided into 12 themed sections, with each section undergoing an annual review cycle: • Bioelectrochemistry • Electrocatalysis • Electrochemical Materials and Engineering • Energy Storage: Batteries and Supercapacitors • Energy Transformation • Environmental Electrochemistry • Fundamental & Theoretical Electrochemistry • Innovative Methods in Electrochemistry • Organic & Molecular Electrochemistry • Physical & Nano-Electrochemistry • Sensors & Bio-sensors •